Tbio CXXC1 CXXC-type zinc finger protein 1

Protein Summary

Description

Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG. This gene encodes a protein that functions as a transcriptional activator that binds specifically to non-methylated CpG motifs through its CXXC domain. The protein is a component of the SETD1 complex, regulates gene expression and is essential for vertebrate development. [provided by RefSeq, Sep 2015]

Uniprot Accession IDs

• Q9P0U4
• B2RC03
• Q8N2W4
• Q96BC8
• Q9P2V7

Gene Name

• CXXC1

Ensembl ID

• ENST00000285106
• ENSP00000285106
• ENSG00000154832
• ENST00000412036
• ENSP00000390475

Symbol

• CFP1
• CGBP
• PCCX1
• PHF18
• CFP1
• CGBP
• SPP1
• PCCX1
• PHF18
• hCGBP
• ZCGPC1
• HsT2645
• 2410002I16Rik
• 5830420C16Rik

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.98
protein domain	0.92
transcription factor binding site profile	0.87
molecular function	0.86
biological process	0.84

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.12   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 240   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.12   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 240   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0