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Tdark
TMEM14C
Transmembrane protein 14C

Protein Summary
Description
Required for normal heme biosynthesis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000229563
  • ENSP00000229563
  • ENSG00000111843
  • ENST00000541412
  • ENSP00000444561
  • ENST00000642513
  • ENSP00000495127
  • ENSG00000284936
  • ENST00000643226
  • ENSP00000495742

Symbol
  • C6orf53
  • NET26
  • C6orf53
  • HSPC194
  • MSTP073
  • bA421M1.6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.97
transcription factor perturbation
0.88
small molecule perturbation
0.81
histone modification site profile
0.75
tissue sample
0.67


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.27   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.27   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 14C
VGNC:12719
746543
Macaque
transmembrane protein 14C
697976
Mouse
MGI:1913404
66154
Rat
RGD:621692
171432
Dog
transmembrane protein 14C
478720
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 14C
Macaque
transmembrane protein 14C
Mouse
Rat
Dog
transmembrane protein 14C
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9P0S9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (6)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (54)
1 – 10 of 54
TIMM8A
Tbio
Family:  Enzyme
Novelty:  0.00954602
p_int:  0.783496732
p_ni:  0.000030777
p_wrong:  0.21647249
Data Source:  BioPlex
SLC25A39
Tdark
Family:  Transporter
Novelty:  0.16700695
Score:  0.737
Data Source:  STRINGDB
PPOX
Tchem
Family:  Enzyme
Novelty:  0.00652809
Score:  0.718
Data Source:  STRINGDB
TMEM141
Tdark
Novelty:  0.62732191
Score:  0.714
Data Source:  STRINGDB
ENOSF1
Tbio
Family:  Enzyme
Novelty:  0.05583478
Score:  0.713
Data Source:  STRINGDB
HIGD1B
Tdark
Novelty:  0.30493093
Score:  0.707
Data Source:  STRINGDB
MECR
Tbio
Family:  Enzyme
Novelty:  0.01395965
Score:  0.697
Data Source:  STRINGDB
IBA57
Tbio
Family:  Enzyme
Novelty:  0.06327415
Score:  0.688
Data Source:  STRINGDB
SMIM11A
Tdark
Novelty:  6
Score:  0.669
Data Source:  STRINGDB
SDHB
Tchem
Family:  Enzyme
Novelty:  0.0010199
Score:  0.649
Data Source:  STRINGDB
Publication Statistics
PubMed Score  8.27

PubMed score by year
PubTator Score  0.96

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer