Tbio COX16 Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial

Protein Summary

Description

Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase (PubMed:29355485, PubMed:29381136). Promotes the insertion of copper into the active site of cytochrome c oxidase subunit II (MT-CO2/COX2) (PubMed:29355485, PubMed:29381136). Interacts specifically with newly synthesized MT-CO2/COX and its copper center-forming metallochaperones SCO1, SCO2 and COA6 (PubMed:29381136). Probably facilitates MT-CO2/COX2 association with the MITRAC assembly intermediate containing MT-CO1/COX1, thereby participating in merging the MT-CO1/COX1 and MT-CO2/COX2 assembly lines (PubMed:29381136).

Uniprot Accession IDs

• Q9P0S2
• A6NDT5
• A8K3X8
• B8XYC5
• hCOX16

Gene Name

• COX16

Ensembl ID

• ENST00000389912
• ENSP00000374562
• ENSG00000133983

Symbol

• C14orf112
• hCOX16
• HSPC203
• C14orf112

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.9
kinase perturbation	0.88
histone modification site profile	0.82
transcription factor perturbation	0.8
transcription factor binding site profile	0.77

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.83   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 46   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.83   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 46   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (38)

Explore Interacting Targets

1 – 10 of 38

• See Interactions on String-DB

PDIA5

Tbio

Family:  Enzyme

Novelty:  0.06234465

p_int:  0.987327147

p_ni:  0.012672853

Data Source:  BioPlex

FCGR3B

Tbio

Novelty:  0.000429

p_int:  0.910410159

p_ni:  0.089505875

p_wrong:  0.000083966

Score:  0.206

Data Source:  BioPlex,STRINGDB

NYX

Tbio

Novelty:  0.0100148

p_int:  0.892198811

p_ni:  0.104346553

p_wrong:  0.003454636

Score:  0.309

Data Source:  BioPlex,STRINGDB

ERGIC3

Tbio

Novelty:  0.11095443

p_int:  0.835978842

p_ni:  0.158271372

p_wrong:  0.005749786

Score:  0.165

Data Source:  BioPlex,STRINGDB

KDELC2

Tdark

Novelty:  0.7820617

p_int:  0.795997619

p_ni:  0.204002381

Data Source:  BioPlex

LPCAT2

Tbio

Family:  Enzyme

Novelty:  0.02794035

p_int:  0.7536375

p_ni:  0.242862535

p_wrong:  0.003499965

Data Source:  BioPlex

CYCS

Tchem

Novelty:  0.00014004

Score:  0.921

Data Source:  STRINGDB

COA3

Tbio

Family:  Enzyme

Novelty:  0.04949473

Score:  0.695

Data Source:  STRINGDB

COX18

Tbio

Novelty:  0.06288021

Score:  0.641

Data Source:  STRINGDB

COX14

Tbio

Family:  Enzyme

Novelty:  0.09340462

Score:  0.621

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (10)

Reactome (9)

KEGG (1)

Gene expression (Transcription) (R-HSA-74160)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Generic Transcription Pathway	1195 targets	R-HSA-212436
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	RNA Polymerase II Transcription	1314 targets	R-HSA-73857
Reactome	Respiratory electron transport	101 targets	R-HSA-611105

Name	Explore in Pharos	Explore in Source
Gene expression (Transcription)	1452 targets	R-HSA-74160
Generic Transcription Pathway	1195 targets	R-HSA-212436
Metabolism	2112 targets	R-HSA-1430728
RNA Polymerase II Transcription	1314 targets	R-HSA-73857
Respiratory electron transport	101 targets	R-HSA-611105

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (2)

Components (1)

Processes (1)

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GO Term	Evidence	Assigned by
integral component of mitochondrial inner membrane	Inferred from Direct Assay (IDA)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (3)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
low density lipoprotein cholesterol measurement	EFO_0004611	4	4	5		91.4
apolipoprotein B measurement	EFO_0004615	2	2	2		84.5
total cholesterol measurement	EFO_0004574	2	2	2		43.9

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
low density lipoprotein cholesterol measurement	EFO_0004611	5		91.4
apolipoprotein B measurement	EFO_0004615	2		84.5
total cholesterol measurement	EFO_0004574	2		43.9

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UniProt Keyword Find Similar Targets

No Header	No Header
Complete proteome
Membrane
Mitochondrion
Mitochondrion inner membrane
Reference proteome
Transmembrane
Transmembrane helix

GWAS Trait Find Similar Targets

No Header	No Header
apolipoprotein B measurement
low density lipoprotein cholesterol measurement
total cholesterol measurement

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	synaptojanin-2-binding protein [Source:RefSeq peptide;Acc:NP_001247889]
Mouse	cytochrome c oxidase assembly protein 16	MGI:1913522	66272
Rat	COX16, cytochrome c oxidase assembly homolog	RGD:2311610	100302447
Dog	COX16, cytochrome c oxidase assembly homolog	VGNC:50443	100846976
Horse	cytochrome c oxidase assembly protein COX16 homolog, mitochondrial-like		102150457

Species	Name	OMA	EggNOG	Inparanoid
Macaque	synaptojanin-2-binding protein [Source:RefSeq peptide;Acc:NP_001247889]
Mouse	cytochrome c oxidase assembly protein 16
Rat	COX16, cytochrome c oxidase assembly homolog
Dog	COX16, cytochrome c oxidase assembly homolog
Horse	cytochrome c oxidase assembly protein COX16 homolog, mitochondrial-like

Publication Statistics

PubMed Score 5.83

PubMed score by year

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PubTator Score 2.91

PubTator score by year

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Related Publications

Text Mined References (10)

GeneRif Annotations (3)

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PMID	Year	Title