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Tbio
COX16
Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial

Protein Summary
Description
Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase (PubMed:29355485, PubMed:29381136). Promotes the insertion of copper into the active site of cytochrome c oxidase subunit II (MT-CO2/COX2) (PubMed:29355485, PubMed:29381136). Interacts specifically with newly synthesized MT-CO2/COX and its copper center-forming metallochaperones SCO1, SCO2 and COA6 (PubMed:29381136). Probably facilitates MT-CO2/COX2 association with the MITRAC assembly intermediate containing MT-CO1/COX1, thereby participating in merging the MT-CO1/COX1 and MT-CO2/COX2 assembly lines (PubMed:29381136).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000389912
  • ENSP00000374562
  • ENSG00000133983

Symbol
  • C14orf112
  • hCOX16
  • HSPC203
  • C14orf112
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.9
kinase perturbation
0.88
histone modification site profile
0.82
transcription factor perturbation
0.8
transcription factor binding site profile
0.77


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.83   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 46   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.83   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 46   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (38)
PDIA5
Tbio
Family:  Enzyme
Novelty:  0.06234465
p_int:  0.987327147
p_ni:  0.012672853
Data Source:  BioPlex
FCGR3B
Tbio
Novelty:  0.000429
p_int:  0.910410159
p_ni:  0.089505875
p_wrong:  0.000083966
Score:  0.206
Data Source:  BioPlex,STRINGDB
NYX
Tbio
Novelty:  0.0100148
p_int:  0.892198811
p_ni:  0.104346553
p_wrong:  0.003454636
Score:  0.309
Data Source:  BioPlex,STRINGDB
ERGIC3
Tbio
Novelty:  0.11095443
p_int:  0.835978842
p_ni:  0.158271372
p_wrong:  0.005749786
Score:  0.165
Data Source:  BioPlex,STRINGDB
KDELC2
Tdark
Novelty:  0.7820617
p_int:  0.795997619
p_ni:  0.204002381
Data Source:  BioPlex
LPCAT2
Tbio
Family:  Enzyme
Novelty:  0.02794035
p_int:  0.7536375
p_ni:  0.242862535
p_wrong:  0.003499965
Data Source:  BioPlex
CYCS
Tchem
Novelty:  0.00014004
Score:  0.921
Data Source:  STRINGDB
COA3
Tbio
Family:  Enzyme
Novelty:  0.04949473
Score:  0.695
Data Source:  STRINGDB
COX18
Tbio
Novelty:  0.06288021
Score:  0.641
Data Source:  STRINGDB
COX14
Tbio
Family:  Enzyme
Novelty:  0.09340462
Score:  0.621
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism
Reactome
RNA Polymerase II Transcription
Reactome
Respiratory electron transport
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism
RNA Polymerase II Transcription
Respiratory electron transport
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
4
4
5
91.4
apolipoprotein B measurement
2
2
2
84.5
total cholesterol measurement
2
2
2
43.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
5
91.4
apolipoprotein B measurement
2
84.5
total cholesterol measurement
2
43.9
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
synaptojanin-2-binding protein [Source:RefSeq peptide;Acc:NP_001247889]
Mouse
MGI:1913522
66272
Rat
RGD:2311610
100302447
Dog
COX16, cytochrome c oxidase assembly homolog
VGNC:50443
100846976
Horse
cytochrome c oxidase assembly protein COX16 homolog, mitochondrial-like
102150457
Species
Name
OMA
EggNOG
Inparanoid
Macaque
synaptojanin-2-binding protein [Source:RefSeq peptide;Acc:NP_001247889]
Mouse
Rat
Dog
COX16, cytochrome c oxidase assembly homolog
Horse
cytochrome c oxidase assembly protein COX16 homolog, mitochondrial-like
Publication Statistics
PubMed Score 5.83
PubMed score by year
PubTator Score 2.91
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title