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Tbio
COX16
Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial

Protein Summary
Description
Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase (PubMed:29355485, PubMed:29381136). Promotes the insertion of copper into the active site of cytochrome c oxidase subunit II (MT-CO2/COX2) (PubMed:29355485, PubMed:29381136). Interacts specifically with newly synthesized MT-CO2/COX and its copper center-forming metallochaperones SCO1, SCO2 and COA6 (PubMed:29381136). Probably facilitates MT-CO2/COX2 association with the MITRAC assembly intermediate containing MT-CO1/COX1, thereby participating in merging the MT-CO1/COX1 and MT-CO2/COX2 assembly lines (PubMed:29381136).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000389912
  • ENSP00000374562
  • ENSG00000133983

Symbol
  • C14orf112
  • hCOX16
  • HSPC203
  • C14orf112
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.9
kinase perturbation
0.88
histone modification site profile
0.82
transcription factor perturbation
0.8
transcription factor binding site profile
0.77


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.83   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 46   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.83   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 46   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
2
2
3
74.5
apolipoprotein B measurement
1
1
1
56.3
total cholesterol measurement
1
1
1
41.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
3
74.5
apolipoprotein B measurement
1
56.3
total cholesterol measurement
1
41.5
Pathways (10)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism
Reactome
RNA Polymerase II Transcription
Reactome
Respiratory electron transport
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism
RNA Polymerase II Transcription
Respiratory electron transport
Protein-Protein Interactions (38)
1 – 10 of 38
PDIA5
Tbio
Family: Enzyme
Novelty: 0.06234465
p_int: 0.987327147
p_ni: 0.012672853
Data Source: BioPlex
FCGR3B
Tbio
Novelty: 0.000429
p_int: 0.910410159
p_ni: 0.089505875
p_wrong: 0.000083966
Score: 0.206
Data Source: BioPlex,STRINGDB
NYX
Tbio
Novelty: 0.0100148
p_int: 0.892198811
p_ni: 0.104346553
p_wrong: 0.003454636
Score: 0.309
Data Source: BioPlex,STRINGDB
ERGIC3
Tbio
Novelty: 0.11095443
p_int: 0.835978842
p_ni: 0.158271372
p_wrong: 0.005749786
Score: 0.165
Data Source: BioPlex,STRINGDB
KDELC2
Tdark
Novelty: 0.7820617
p_int: 0.795997619
p_ni: 0.204002381
Data Source: BioPlex
LPCAT2
Tbio
Family: Enzyme
Novelty: 0.02794035
p_int: 0.7536375
p_ni: 0.242862535
p_wrong: 0.003499965
Data Source: BioPlex
CYCS
Tchem
Novelty: 0.00014004
Score: 0.921
Data Source: STRINGDB
COA3
Tbio
Family: Enzyme
Novelty: 0.04949473
Score: 0.695
Data Source: STRINGDB
COX18
Tbio
Novelty: 0.06288021
Score: 0.641
Data Source: STRINGDB
COX14
Tbio
Family: Enzyme
Novelty: 0.09340462
Score: 0.621
Data Source: STRINGDB
Publication Statistics
PubMed Score  5.83

PubMed score by year
PubTator Score  2.91

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer