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Tbio
TBC1D7
TBC1 domain family member 7

Protein Summary
Description
Component of the TSC-TBC complex, that contains TBC1D7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward RHEB in response to alterations in specific cellular growth conditions. The small GTPase RHEB is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB. Participates in the proper sensing of growth factors and glucose, but not amino acids, by mTORC1. It is unclear whether TBC1D7 acts as a GTPase-activating protein and additional studies are required to answer this question. This locus represents naturally occurring readthrough transcription between the neighboring TBC1D7 (TBC1 domain family member 7) gene and downstream uncharacterized LOC100130357 on chromosome 6. Readthrough transcripts may encode the same protein as TBC1 domain family member 7 or may be candidates for nonsense-mediate ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343141
  • ENSP00000343100
  • ENSG00000145979
  • ENST00000356436
  • ENSP00000348813
  • ENST00000379300
  • ENSP00000368602
  • ENST00000379307
  • ENSP00000368609
  • ENST00000606214
  • ENSP00000475727

Symbol
  • TBC7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
transcription factor
0.79
virus perturbation
0.76
transcription factor binding site profile
0.74
transcription factor perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.46   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 88   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.46   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (12)
Membrane Trafficking (R-HSA-199991)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Membrane Trafficking
Reactome
Rab regulation of trafficking
Reactome
TBC/RABGAPs
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Membrane Trafficking
Rab regulation of trafficking
TBC/RABGAPs
Vesicle-mediated transport
Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (89)
1 – 10 of 89
TSC1
Tbio
Novelty: 0.00606799
p_int: 1
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
KIF27
Tbio
Novelty: 0.16606926
p_int: 0.999999976
p_ni: 1.3e-8
p_wrong: 1.1e-8
Score: 0.68
Data Source: BioPlex,STRINGDB
TSC2
Tbio
Novelty: 0.00092908
p_int: 0.998400748
p_ni: 0.001599251
p_wrong: 1e-9
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
RHEB
Tbio
Family: Enzyme
Novelty: 0.00441245
Score: 0.949
Data Source: STRINGDB
AKT1
Tchem
Family: Kinase
Novelty: 0.0000383
Score: 0.879
Data Source: STRINGDB
DDIT4
Tbio
Novelty: 0.00650886
Score: 0.864
Data Source: STRINGDB
RPS6KA1
Tchem
Family: Kinase
Novelty: 0.00250734
Score: 0.863
Data Source: STRINGDB
RPS6KA2
Tchem
Family: Kinase
Novelty: 0.00638792
Score: 0.852
Data Source: STRINGDB
RPS6KA3
Tchem
Family: Kinase
Novelty: 0.00292563
Score: 0.847
Data Source: STRINGDB
AKT3
Tchem
Family: Kinase
Novelty: 0.00482543
Score: 0.815
Data Source: STRINGDB
Publication Statistics
PubMed Score  9.46

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer