You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
TBC1D7
TBC1 domain family member 7

Protein Summary
Description
Component of the TSC-TBC complex, that contains TBC1D7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward RHEB in response to alterations in specific cellular growth conditions. The small GTPase RHEB is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB. Participates in the proper sensing of growth factors and glucose, but not amino acids, by mTORC1. It is unclear whether TBC1D7 acts as a GTPase-activating protein and additional studies are required to answer this question. This locus represents naturally occurring readthrough transcription between the neighboring TBC1D7 (TBC1 domain family member 7) gene and downstream uncharacterized LOC100130357 on chromosome 6. Readthrough transcripts may encode the same protein as TBC1 domain family member 7 or may be candidates for nonsense-mediate ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343141
  • ENSP00000343100
  • ENSG00000145979
  • ENST00000356436
  • ENSP00000348813
  • ENST00000379300
  • ENSP00000368602
  • ENST00000379307
  • ENSP00000368609
  • ENST00000606214
  • ENSP00000475727

Symbol
  • TBC7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
transcription factor
0.79
virus perturbation
0.76
transcription factor binding site profile
0.74
transcription factor perturbation
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.71   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 88   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.71   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
52
mathematical ability
1
1
1
43.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
52
mathematical ability
1
43.8
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TBC1 domain family member 7
VGNC:3725
462439
Macaque
TBC1 domain family member 7
706015
Mouse
MGI:1914296
67046
Rat
RGD:1307661
361227
Dog
TBC1 domain family member 7
VGNC:49771
478725
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TBC1 domain family member 7
Macaque
TBC1 domain family member 7
Mouse
Rat
Dog
TBC1 domain family member 7
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9P0N9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (12)
Membrane Trafficking (R-HSA-199991)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Membrane Trafficking
Reactome
Rab regulation of trafficking
Reactome
TBC/RABGAPs
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Membrane Trafficking
Rab regulation of trafficking
TBC/RABGAPs
Vesicle-mediated transport
Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (89)
1 – 10 of 89
TSC1
Tbio
Novelty: 0.00406614
p_int: 1
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
KIF27
Tbio
Novelty: 0.16575818
p_int: 0.999999976
p_ni: 1.3e-8
p_wrong: 1.1e-8
Score: 0.68
Data Source: BioPlex,STRINGDB
TSC2
Tbio
Novelty: 0.00067416
p_int: 0.998400748
p_ni: 0.001599251
p_wrong: 1e-9
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
RHEB
Tbio
Family: Enzyme
Novelty: 0.00313935
Score: 0.949
Data Source: STRINGDB
AKT1
Tchem
Family: Kinase
Novelty: 0.00003185
Score: 0.879
Data Source: STRINGDB
DDIT4
Tbio
Novelty: 0.00464348
Score: 0.864
Data Source: STRINGDB
RPS6KA1
Tchem
Family: Kinase
Novelty: 0.00178073
Score: 0.863
Data Source: STRINGDB
RPS6KA2
Tchem
Family: Kinase
Novelty: 0.00409407
Score: 0.852
Data Source: STRINGDB
RPS6KA3
Tchem
Family: Kinase
Novelty: 0.00221219
Score: 0.847
Data Source: STRINGDB
AKT3
Tchem
Family: Kinase
Novelty: 0.00308931
Score: 0.815
Data Source: STRINGDB
Publication Statistics
PubMed Score  12.71

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer