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Tbio
MARCH2
E3 ubiquitin-protein ligase MARCH2

Protein Summary
Description
E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in endosomal trafficking through interaction with STX6. MARCH2 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH2 reduces surface accumulation of several glycoproteins and appears to regulate early endosome-to-trans-Golgi network (TGN) trafficking (Bartee et al., 2004 [PubMed 14722266]; Nakamura et al., 2005 [PubMed 15689499]).[supplied by OMIM, Mar 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000215555
  • ENSP00000215555
  • ENSG00000099785
  • ENST00000381035
  • ENSP00000370423
  • ENST00000602117
  • ENSP00000471536

Symbol
  • RNF172
  • RNF172
  • HSPC240
  • MARCH-II
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.85
virus perturbation
0.79
histone modification site profile
0.74
cellular component
0.66
tissue sample
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.04   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 182   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.04   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 182   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (55)
PTEN
Tchem
Family:  Enzyme
Novelty:  0.00013818
Score:  0.89
Data Source:  STRINGDB
SPRTN
Tbio
Novelty:  0.0388393
Score:  0.87
Data Source:  STRINGDB
STX6
Tbio
Novelty:  0.01494028
Score:  0.834
Data Source:  STRINGDB
GRASP
Tbio
Novelty:  0.00206067
Score:  0.825
Data Source:  STRINGDB
MARCH5
Tbio
Family:  Epigenetic
Novelty:  0.02702094
Score:  0.764
Data Source:  STRINGDB
TGOLN2
Tbio
Novelty:  0.005107
Score:  0.715
Data Source:  STRINGDB
CDC34
Tbio
Novelty:  0.00650407
Score:  0.69
Data Source:  STRINGDB
UBE2H
Tbio
Novelty:  0.03259425
Score:  0.688
Data Source:  STRINGDB
SKP2
Tbio
Family:  Enzyme
Novelty:  0.00182658
Score:  0.657
Data Source:  STRINGDB
RNF170
Tbio
Family:  Enzyme
Novelty:  0.1117879
Score:  0.638
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (1)
Find Similar Targets
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
UniProt
Protein modification; protein ubiquitination.
Name
Explore in Pharos
Explore in Source
Protein modification; protein ubiquitination.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
13
9
21
4
99.6
apolipoprotein A 1 measurement
2
4
5
98
triglyceride measurement
9
3
12
98
reticulocyte measurement
3
5
7
85.7
mean corpuscular hemoglobin concentration
1
1
1
83.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
21
4
99.6
apolipoprotein A 1 measurement
5
98
triglyceride measurement
12
98
reticulocyte measurement
7
85.7
mean corpuscular hemoglobin concentration
1
83.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
membrane associated ring-CH-type finger 2
743428
Mouse
MGI:1925915
224703
Rat
RGD:1306395
362849
Dog
membrane associated ring-CH-type finger 2
VGNC:43015
611624
Horse
membrane associated ring-CH-type finger 2
VGNC:19975
100049857
Species
Name
OMA
EggNOG
Inparanoid
Chimp
membrane associated ring-CH-type finger 2
Mouse
Rat
Dog
membrane associated ring-CH-type finger 2
Horse
membrane associated ring-CH-type finger 2
Publication Statistics
PubMed Score 15.04
PubMed score by year
PubTator Score 107.26
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title