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Tbio
H2AFY2
Core histone macro-H2A.2

Protein Summary
Description
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form high ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373255
  • ENSP00000362352
  • ENSG00000099284

Symbol
  • MACROH2A2
  • macroH2A2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
molecular function
0.7
cellular component
0.69
biological process
0.67
transcription factor binding site profile
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.85   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 302   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.85   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 302   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eyelid sagging measurement
1
1
0
4
10.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eyelid sagging measurement
0
4
10.7
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
H2A histone family member Y2
VGNC:5462
450509
Macaque
H2A histone family, member Y2
711117
Mouse
MGI:3037658
404634
Rat
RGD:1561371
361844
Dog
core histone macro-H2A.2
489024
Species
Name
OMA
EggNOG
Inparanoid
Chimp
H2A histone family member Y2
Macaque
H2A histone family, member Y2
Mouse
Rat
Dog
core histone macro-H2A.2
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9P0M6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Systemic lupus erythematosus
KEGG
Necroptosis
KEGG
Alcoholism
Name
Explore in Pharos
Explore in Source
Systemic lupus erythematosus
Necroptosis
Alcoholism
Gene Ontology Terms (20)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (182)
1 – 10 of 182
H2AFY
Tbio
Novelty: 0.01150729
p_int: 0.999999718
p_ni: 2.82e-7
Score: 0.766
Data Source: BioPlex,STRINGDB
TUBA8
Tbio
Novelty: 0.06454549
p_int: 0.999997196
p_ni: 0.000002804
Score: 0.267
Data Source: BioPlex,STRINGDB
HIST1H4A
Tbio
Novelty: 0.00279614
p_int: 0.999983506
p_ni: 0.000010107
p_wrong: 0.000006387
Score: 0.787
Data Source: BioPlex,STRINGDB
APLF
Tbio
Novelty: 0.01347476
p_int: 0.999964233
p_ni: 0.000035757
p_wrong: 1e-8
Score: 0.551
Data Source: BioPlex,STRINGDB
HIST1H2BA
Tbio
Novelty: 0.02431803
p_int: 0.999595968
p_ni: 0.000004762
p_wrong: 0.000399271
Score: 0.963
Data Source: BioPlex,STRINGDB
TONSL
Tbio
Novelty: 0.07220129
p_int: 0.999569596
p_ni: 0.000430404
Score: 0.186
Data Source: BioPlex,STRINGDB
IPO9
Tbio
Novelty: 0.03978028
p_int: 0.999402564
p_ni: 0.000597436
Score: 0.297
Data Source: BioPlex,STRINGDB
DNAAF2
Tbio
Novelty: 0.01254416
p_int: 0.999292683
p_ni: 0.000706849
p_wrong: 4.68e-7
Data Source: BioPlex
ZNF189
Tdark
Family: TF
Novelty: 0.28362251
p_int: 0.999260127
p_ni: 0.000739694
p_wrong: 1.79e-7
Score: 0.159
Data Source: BioPlex,STRINGDB
MMS22L
Tbio
Novelty: 0.22570578
p_int: 0.999254751
p_ni: 0.000744845
p_wrong: 4.04e-7
Score: 0.15
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  8.85

PubMed score by year
PubTator Score  9.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer