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Tbio
Q9P0M2
A-kinase anchor protein 7 isoform gamma

Protein Summary
Description
Probably targets cAMP-dependent protein kinase (PKA) to the cellular membrane or cytoskeletal structures. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium. This gene encodes a member of the A-kinase anchoring protein (AKAP) family, a group of functionally related proteins that bind to a regulatory subunit (RII) of cAMP-dependent protein kinase A (PKA) and target the enzyme to specific subcellular compartments. AKAPs have a common RII-binding domain, but contain different targeting motifs responsible for directing PKA to distinct intracellular locations. Three alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Apr 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000431975
  • ENSP00000405252
  • ENSG00000118507

Symbol
  • AKAP18
  • AKAP15
  • AKAP18
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.86
histone modification site profile
0.86
disease perturbation
0.79
microRNA
0.68
virus perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.78   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 250   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.78   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 250   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (79)
PRKAR2B
Tchem
Family:  Enzyme
Novelty:  0.00456972
p_int:  0.999999492
p_ni:  4.94e-7
p_wrong:  1.4e-8
Score:  0.502
Data Source:  BioPlex,STRINGDB
LSM5
Tbio
Novelty:  0.12669584
p_int:  0.999999214
p_ni:  7.85e-7
Score:  0.549
Data Source:  BioPlex,STRINGDB
PRKACB
Tchem
Family:  Kinase
Novelty:  0.01962222
p_int:  0.99999896
p_ni:  0.000001018
p_wrong:  2.2e-8
Score:  0.606
Data Source:  BioPlex,STRINGDB
LSM6
Tbio
Novelty:  0.09507671
p_int:  0.999997378
p_ni:  0.000002592
p_wrong:  3e-8
Score:  0.71
Data Source:  BioPlex,STRINGDB
PRPF3
Tbio
Novelty:  0.01600014
p_int:  0.999991892
p_ni:  0.000008107
p_wrong:  1e-9
Score:  0.821
Data Source:  BioPlex,STRINGDB
SNRPE
Tbio
Novelty:  0.02033423
p_int:  0.999916003
p_ni:  0.000083994
p_wrong:  3e-9
Score:  0.499
Data Source:  BioPlex,STRINGDB
PRKACG
Tchem
Family:  Kinase
Novelty:  0.11080061
p_int:  0.996835277
p_ni:  0.003164721
p_wrong:  2e-9
Score:  0.823
Data Source:  BioPlex,STRINGDB
SNRPGP15
Tdark
p_int:  0.996767584
p_ni:  0.000213106
p_wrong:  0.00301931
Data Source:  BioPlex
SNRPF
Tbio
Novelty:  0.17624854
p_int:  0.993966582
p_ni:  0.00603335
p_wrong:  6.8e-8
Score:  0.557
Data Source:  BioPlex,STRINGDB
SNRPN
Tbio
Novelty:  0.002157
p_int:  0.970629851
p_ni:  0.00154742
p_wrong:  0.027822729
Score:  0.387
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
1
2
78.9
balding measurement
1
1
2
78.9
body height
1
1
2
71.9
body height
1
1
2
71.9
mean corpuscular volume
1
1
2
68.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
2
78.9
balding measurement
2
78.9
body height
2
71.9
body height
2
71.9
mean corpuscular volume
2
68.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
A-kinase anchoring protein 7
VGNC:2664
462998
Macaque
A-kinase anchoring protein 7
710509
Mouse
MGI:1859150
432442
Rat
RGD:1303071
361458
Dog
A-kinase anchoring protein 7
VGNC:37760
484128
Species
Name
OMA
EggNOG
Inparanoid
Chimp
A-kinase anchoring protein 7
Macaque
A-kinase anchoring protein 7
Mouse
Rat
Dog
A-kinase anchoring protein 7
Publication Statistics
PubMed Score 36.78
PubMed score by year
PubTator Score 20.59
PubTator score by year
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Related Publications
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PMID
Year
Title