Tchem PKD2L1 Polycystic kidney disease 2-like 1 protein

Protein Summary

Description

Pore-forming subunit of a heterotetrameric, non-selective cation channel that is permeable to Ca(2+) (PubMed:10517637, PubMed:11959145, PubMed:25820328, PubMed:27754867, PubMed:29425510, PubMed:23212381, PubMed:30004384). Pore-forming subunit of a calcium-permeant ion channel formed by PKD1L2 and PKD1L1 in primary cilia, where it controls cilium calcium concentration, but does not affect cytoplasmic calcium concentration (PubMed:24336289). The channel formed by PKD1L2 and PKD1L1 in primary cilia regulates sonic hedgehog/SHH signaling and GLI2 transcription (PubMed:24336289). Pore-forming subunit of a channel formed by PKD1L2 and PKD1L3 that contributes to sour taste perception in gustatory cells (PubMed:19812697). The heteromeric channel formed by PKD1L2 and PKD1L3 is activated by low pH, but opens only when the extracellular pH rises again (PubMed:23212381). May play a role in the perception of carbonation taste (By similarity). May play a role in the sensory perception of water, via a mechanism that activates the channel in response to dilution of salivary bicarbonate and changes in salivary pH (By similarity). This gene encodes a member of the polycystin protein family. The encoded protein contains multiple transmembrane domains, and cytoplasmic N- and C-termini. The protein may be an integral membrane protein involved in cell-cell/matrix interactions. This protein functions as a calcium-regulated nonselective cation channel. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Uniprot Accession IDs

• Q9P0L9
• O75972
• Q5W039
• Q9UP35
• Q9UPA2

Gene Name

• PKD2L1

Ensembl ID

• ENST00000318222
• ENSP00000325296
• ENSG00000107593

Symbol

• PKD2L
• PKDL
• TRPP3
• PCL
• PKDL
• PKD2L
• TRPP3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
cellular component	0.69
gene perturbation	0.65
biological process	0.55
ligand (chemical)	0.54

Protein Classes

PANTHER Classes

Protein / Transporter / Ion Channel / Polycystic Kidney Disease 2-like 1 Protein

Protein / Signaling Molecule / Membrane-bound Signaling Molecule / Polycystic Kidney Disease 2-like 1 Protein

Protein / Enzyme Modulator / G-protein Modulator / Polycystic Kidney Disease 2-like 1 Protein

Protein / ... / Protease / Polycystic Kidney Disease 2-like 1 Protein

DTO Classes

Protein / Ion Channel / Polycystin Cation Channel (Pcc) Family / Polycystic Kidney Disease 2-like 1 Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.52   (req: < 5)

Gene RIFs: 20   (req: <= 3)

Antibodies: 118   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.52   (req: >= 5)

Gene RIFs: 20   (req: > 3)

Antibodies: 118   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1