You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
PKD2L1
Polycystic kidney disease 2-like 1 protein

Protein Classes
Protein Summary
Description
Pore-forming subunit of a heterotetrameric, non-selective cation channel that is permeable to Ca(2+) (PubMed:10517637, PubMed:11959145, PubMed:25820328, PubMed:27754867, PubMed:29425510, PubMed:23212381, PubMed:30004384). Pore-forming subunit of a calcium-permeant ion channel formed by PKD1L2 and PKD1L1 in primary cilia, where it controls cilium calcium concentration, but does not affect cytoplasmic calcium concentration (PubMed:24336289). The channel formed by PKD1L2 and PKD1L1 in primary cilia regulates sonic hedgehog/SHH signaling and GLI2 transcription (PubMed:24336289). Pore-forming subunit of a channel formed by PKD1L2 and PKD1L3 that contributes to sour taste perception in gustatory cells (PubMed:19812697). The heteromeric channel formed by PKD1L2 and PKD1L3 is activated by low pH, but opens only when the extracellular pH rises again (PubMed:23212381). May play a role in the perception of carbonation taste (By similarity). May play a role in the sensory perception of water, via ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318222
  • ENSP00000325296
  • ENSG00000107593

Symbol
  • PKD2L
  • PKDL
  • TRPP3
  • PCL
  • PKDL
  • PKD2L
  • TRPP3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
cellular component
0.69
gene perturbation
0.65
biological process
0.55
ligand (chemical)
0.54


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.72   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 118   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.72   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 118   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
amiloride
chemical structure image
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
1
4
92.6
blood metabolite measurement
3
1
6
90.4
metabolite measurement
1
1
1
89.7
mean platelet volume
3
1
3
84.8
glycerophospholipid measurement
1
1
1
74.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
4
92.6
blood metabolite measurement
6
90.4
metabolite measurement
1
89.7
mean platelet volume
3
84.8
glycerophospholipid measurement
1
74.5
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
polycystin 2 like 1, transient receptor potential cation channel
VGNC:14782
466255
Macaque
polycystin 2 like 1, transient receptor potential cation channel
710056
Mouse
MGI:1352448
329064
Rat
RGD:1306261
293937
Dog
polycystin 2 like 1, transient receptor potential cation channel
VGNC:44601
486838
Species
Name
OMA
EggNOG
Inparanoid
Chimp
polycystin 2 like 1, transient receptor potential cation channel
Macaque
polycystin 2 like 1, transient receptor potential cation channel
Mouse
Rat
Dog
polycystin 2 like 1, transient receptor potential cation channel
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9P0L9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (34)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Protein-Protein Interactions (76)
1 – 10 of 76
PKD1L3
Tbio
Family: IC
Novelty: 0.0517368
Score: 0.933
Data Source: STRINGDB
TRPM5
Tchem
Family: IC
Novelty: 0.00708583
Score: 0.768
Data Source: STRINGDB
TAS1R1
Tbio
Family: GPCR
Novelty: 0.00913004
Score: 0.765
Data Source: STRINGDB
TAS1R3
Tbio
Family: GPCR
Novelty: 0.00370936
Score: 0.764
Data Source: STRINGDB
PKD1L2
Tbio
Family: IC
Novelty: 0.17684334
Score: 0.761
Data Source: STRINGDB
TAS1R2
Tbio
Family: GPCR
Novelty: 0.00568766
Score: 0.753
Data Source: STRINGDB
ENTPD7
Tbio
Family: Enzyme
Novelty: 0.1810079
Score: 0.706
Data Source: STRINGDB
SCNN1B
Tclin
Family: IC
Novelty: 0.01281284
Score: 0.701
Data Source: STRINGDB
TRPA1
Tclin
Family: IC
Novelty: 0.00093648
Score: 0.67
Data Source: STRINGDB
MCOLN3
Tchem
Family: IC
Novelty: 0.03209262
Score: 0.663
Data Source: STRINGDB
Publication Statistics
PubMed Score  71.72

PubMed score by year
PubTator Score  64.41

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: