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Tchem
MARK1
Serine/threonine-protein kinase MARK1

Protein Summary
Description
Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366917
  • ENSP00000355884
  • ENSG00000116141
  • ENST00000366918
  • ENSP00000355885

Symbol
  • KIAA1477
  • MARK
  • MARK
  • Par1c
  • Par-1c
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
protein domain
0.97
kinase perturbation
0.88
microRNA
0.86
virus perturbation
0.85


Related Tools
Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.77   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 423   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.77   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 423   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
microtubule affinity regulating kinase 1
VGNC:8075
469683
Macaque
microtubule affinity regulating kinase 1
710695
Mouse
MGI:2664902
226778
Rat
RGD:619882
117016
Dog
microtubule affinity regulating kinase 1
VGNC:49921
478965
Species
Name
OMA
EggNOG
Inparanoid
Chimp
microtubule affinity regulating kinase 1
Macaque
microtubule affinity regulating kinase 1
Mouse
Rat
Dog
microtubule affinity regulating kinase 1
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (40)
Items per page:
1 – 5 of 40
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Regulation of Microtubule Cytoskeleton
WikiPathways
Regulation of Microtubule Cytoskeleton
WikiPathways
Regulation of Microtubule Cytoskeleton
WikiPathways
Regulation of Microtubule Cytoskeleton
WikiPathways
Pregnane X Receptor pathway
Name
Explore in Pharos
Explore in Source
Regulation of Microtubule Cytoskeleton
Regulation of Microtubule Cytoskeleton
Regulation of Microtubule Cytoskeleton
Regulation of Microtubule Cytoskeleton
Pregnane X Receptor pathway
Gene Ontology Terms (23)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Protein-Protein Interactions (41)
1 – 10 of 41
COL4A3BP
Tbio
Novelty: 0.00357203
p_int: 0.999999999
p_ni: 1e-9
Score: 0.269
Data Source: BioPlex,STRINGDB
GPSM3
Tbio
Novelty: 0.01632501
p_int: 0.999852211
p_ni: 0.000147657
p_wrong: 1.32e-7
Data Source: BioPlex
CDH19
Tbio
Novelty: 0.0759041
p_int: 0.996925867
p_ni: 0.000040408
p_wrong: 0.003033725
Score: 0.242
Data Source: BioPlex,STRINGDB
HSPBAP1
Tbio
Novelty: 0.03321047
Score: 0.662
Data Source: STRINGDB
MAP4
Tbio
Novelty: 0.00391218
Score: 0.632
Data Source: STRINGDB
MAP2
Tchem
Novelty: 0.00068493
Score: 0.631
Data Source: STRINGDB
MAPT
Tchem
Novelty: 0.00013232
Score: 0.624
Data Source: STRINGDB
ZC3H14
Tbio
Novelty: 0.07532778
Score: 0.623
Data Source: STRINGDB
USP21
Tbio
Family: Enzyme
Novelty: 0.11434352
Score: 0.622
Data Source: STRINGDB
YWHAQ
Tchem
Novelty: 0.00234496
Score: 0.606
Data Source: STRINGDB
Publication Statistics
PubMed Score  36.77

PubMed score by year
PubTator Score  1042.16

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer