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Tbio
VAPA
Vesicle-associated membrane protein-associated protein A

Protein Summary
Description
Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:25447204). With OSBPL3, may regulate ER morphology (PubMed:16143324). May play a role in vesicle trafficking (PubMed:11511104, PubMed:19289470). The protein encoded by this gene is a type IV membrane protein. It is present in the plasma membrane and intracellular vesicles. It may also be associated with the cytoskeleton. This protein may function in vesicle trafficking, membrane fusion, protein complex assembly and cell motility. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340541
  • ENSP00000345656
  • ENSG00000101558
  • ENST00000400000
  • ENSP00000382880

Symbol
  • VAP33
  • VAP-A
  • VAP33
  • VAP-33
  • hVAP-33
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
kinase perturbation
1
disease perturbation
0.99
virus perturbation
0.98
transcription factor binding site profile
0.87


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 555.12   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 248   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 555.12   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 248   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
2
2
86.8
heel bone mineral density
2
2
2
24.1
peak expiratory flow
1
1
1
14.1
FEV/FEC ratio
1
1
1
7.7
forced expiratory volume
1
1
1
2.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
2
86.8
heel bone mineral density
2
24.1
peak expiratory flow
1
14.1
FEV/FEC ratio
1
7.7
forced expiratory volume
1
2.3
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1353561
30960
Rat
RGD:61803
58857
Dog
VAMP associated protein A
VGNC:48229
480208
Cow
VAMP associated protein A
VGNC:36763
516024
Platypus
VAMP associated protein A
100081514
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
VAMP associated protein A
Cow
VAMP associated protein A
Platypus
VAMP associated protein A
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (17)
Competing endogenous RNAs (ceRNAs) regulate PTEN translation (R-HSA-8948700)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Competing endogenous RNAs (ceRNAs) regulate PTEN translation
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Reactome
Intracellular signaling by second messengers
Name
Explore in Pharos
Explore in Source
Competing endogenous RNAs (ceRNAs) regulate PTEN translation
Immune System
Innate Immune System
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Intracellular signaling by second messengers
Gene Ontology Terms (27)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Protein-Protein Interactions (288)
1 – 10 of 288
OSBPL2
Tbio
Novelty: 0.03946704
p_int: 1
Score: 0.813
Data Source: BioPlex,STRINGDB
VAPB
Tbio
Novelty: 0.00542377
p_int: 0.999999999
p_ni: 1e-9
Score: 0.956
Data Source: BioPlex,STRINGDB
PITPNM1
Tbio
Novelty: 0.0063062
p_int: 0.999999984
p_ni: 1.2e-8
p_wrong: 4e-9
Score: 0.842
Data Source: BioPlex,STRINGDB
ACBD5
Tbio
Novelty: 0.10433432
p_int: 0.999999981
p_ni: 1.8e-8
p_wrong: 1e-9
Score: 0.754
Data Source: BioPlex,STRINGDB
NACAD
Tdark
Novelty: 0.46197991
p_int: 0.999999797
p_ni: 1.85e-7
p_wrong: 1.8e-8
Score: 0.441
Data Source: BioPlex,STRINGDB
ZFPL1
Tbio
Novelty: 0.1829181
p_int: 0.999999789
p_ni: 2.11e-7
Score: 0.196
Data Source: BioPlex,STRINGDB
ARHGEF12
Tbio
Novelty: 0.01365866
p_int: 0.999999734
p_ni: 2.66e-7
Score: 0.16
Data Source: BioPlex,STRINGDB
OSBPL9
Tbio
Novelty: 0.07633459
p_int: 0.999999715
p_ni: 2.83e-7
p_wrong: 2e-9
Score: 0.827
Data Source: BioPlex,STRINGDB
RASSF1
Tbio
Novelty: 0.00137149
p_int: 0.999999631
p_ni: 3.36e-7
p_wrong: 3.2e-8
Score: 0.252
Data Source: BioPlex,STRINGDB
OSBP2
Tbio
Novelty: 0.02589566
p_int: 0.999999606
p_ni: 4.6e-8
p_wrong: 3.49e-7
Score: 0.921
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  555.12

PubMed score by year
PubTator Score  72.29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer