Tbio VAPA Vesicle-associated membrane protein-associated protein A

Protein Summary

Description

Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:25447204). With OSBPL3, may regulate ER morphology (PubMed:16143324). May play a role in vesicle trafficking (PubMed:11511104, PubMed:19289470). The protein encoded by this gene is a type IV membrane protein. It is present in the plasma membrane and intracellular vesicles. It may also be associated with the cytoskeleton. This protein may function in vesicle trafficking, membrane fusion, protein complex assembly and cell motility. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9P0L0
• A6NDZ0
• D3DUI3
• O75453
• Q5U0E7
• Q9UBZ2
• VAMP-A

Gene Name

• VAPA

Ensembl ID

• ENST00000340541
• ENSP00000345656
• ENSG00000101558
• ENST00000400000
• ENSP00000382880

Symbol

• VAP33
• VAP-A
• VAP33
• VAP-33
• hVAP-33

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
kinase perturbation	1
disease perturbation	0.99
virus perturbation	0.98
transcription factor binding site profile	0.87

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Membrane Trafficking Regulatory Protein / Vesicle-associated Membrane Protein-associated Protein A

DTO Classes

Protein / Transporter / Membrane Trafficking Regulatory Protein / Vesicle-associated Membrane Protein-associated Protein A

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 766.94   (req: < 5)

Gene RIFs: 29   (req: <= 3)

Antibodies: 248   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 766.94   (req: >= 5)

Gene RIFs: 29   (req: > 3)

Antibodies: 248   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0