Tbio ADAM22 Disintegrin and metalloproteinase domain-containing protein 22

Protein Summary

Description

Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein (PubMed:19692335). Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1. This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Unlike other members of the ADAM protein family, the protein encoded by this gene lacks metalloprotease activity since it has no zinc-binding motif. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. In mice, it has been shown to be essential for correct myelination in the peripheral nervous system. Alternative splicing results in several transcript variants.[provided by RefSeq, Dec 2010]

Uniprot Accession IDs

• Q9P0K1
• O75075
• O75076
• Q9P0K2
• Q9UIA1
• Q9UKK2
• ADAM 22

Gene Name

• ADAM22

Ensembl ID

• ENST00000265727
• ENSP00000265727
• ENSG00000008277
• ENST00000398201
• ENSP00000381260
• ENST00000398204
• ENSP00000381262
• ENST00000398209
• ENSP00000381267

Symbol

• MDC2
• MDC2
• EIEE61
• ADAM 22

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.97
histone modification site profile	0.72
tissue sample	0.71
molecular function	0.7
disease perturbation	0.68

Protein Classes

PANTHER Classes

Protein / ... / Metalloprotease / Disintegrin And Metalloproteinase Domain-containing Protein 22

DTO Classes

Protein / Enzyme / Protease / Metalloprotease / Disintegrin And Metalloproteinase Domain-containing Protein 22

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.47   (req: < 5)

Gene RIFs: 20   (req: <= 3)

Antibodies: 322   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.47   (req: >= 5)

Gene RIFs: 20   (req: > 3)

Antibodies: 322   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0