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Tbio
KCMF1
E3 ubiquitin-protein ligase KCMF1

Protein Summary
Description
Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000409785
  • ENSP00000386738
  • ENSG00000176407

Symbol
  • FIGC
  • ZZZ1
  • FIGC
  • PCMF
  • ZZZ1
  • DEBT91
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
1
virus perturbation
1
transcription factor perturbation
0.97
histone modification site profile
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.09   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 133   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.09   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (3)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Gene Ontology Terms (7)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (57)
1 – 10 of 57
NIPSNAP3A
Tdark
Novelty: 0.39370079
p_int: 0.999952294
p_ni: 0.000047706
Score: 0.186
Data Source: BioPlex,STRINGDB
UBR4
Tbio
Family: Enzyme
Novelty: 0.05991158
p_int: 0.999951708
p_ni: 0.000048292
Score: 0.952
Data Source: BioPlex,STRINGDB
ABHD10
Tbio
Family: Enzyme
Novelty: 0.45049505
p_int: 0.999773878
p_ni: 0.000226122
Score: 0.36
Data Source: BioPlex,STRINGDB
IDH2
Tclin
Family: Enzyme
Novelty: 0.00094359
p_int: 0.999326889
p_ni: 0.000673111
Score: 0.252
Data Source: BioPlex,STRINGDB
LYPD6B
Tdark
Novelty: 0.28952206
p_int: 0.993710774
p_ni: 0.006289226
Data Source: BioPlex
ELP2
Tbio
Novelty: 0.04397676
p_int: 0.992542946
p_ni: 0.007457054
Data Source: BioPlex
SARS2
Tbio
Family: Enzyme
Novelty: 0.00264837
p_int: 0.991974719
p_ni: 0.008025281
Score: 0.234
Data Source: BioPlex,STRINGDB
TESPA1
Tbio
Novelty: 0.16468435
p_int: 0.981058585
p_ni: 0.018941408
p_wrong: 7e-9
Score: 0.179
Data Source: BioPlex,STRINGDB
A1BG
Tbio
Novelty: 0.00328298
p_int: 0.980462808
p_ni: 0.019536927
p_wrong: 2.66e-7
Score: 0.532
Data Source: BioPlex,STRINGDB
FSTL4
Tdark
Novelty: 1.47727273
p_int: 0.976065345
p_ni: 0.023934655
Score: 0.815
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  27.09

PubMed score by year
PubTator Score  5.43

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer