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Tbio
KCMF1
E3 ubiquitin-protein ligase KCMF1

Protein Summary
Description
Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000409785
  • ENSP00000386738
  • ENSG00000176407

Symbol
  • FIGC
  • ZZZ1
  • FIGC
  • PCMF
  • ZZZ1
  • DEBT91
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
1
virus perturbation
1
transcription factor perturbation
0.97
histone modification site profile
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.04   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 133   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.04   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (57)
1 – 10 of 57
NIPSNAP3A
Tdark
Novelty:  0.45687717
p_int:  0.999952294
p_ni:  0.000047706
Score:  0.186
Data Source:  BioPlex,STRINGDB
UBR4
Tbio
Family:  Enzyme
Novelty:  0.03924839
p_int:  0.999951708
p_ni:  0.000048292
Score:  0.952
Data Source:  BioPlex,STRINGDB
ABHD10
Tbio
Family:  Enzyme
Novelty:  0.26168446
p_int:  0.999773878
p_ni:  0.000226122
Score:  0.36
Data Source:  BioPlex,STRINGDB
IDH2
Tclin
Family:  Enzyme
Novelty:  0.00131782
p_int:  0.999326889
p_ni:  0.000673111
Score:  0.252
Data Source:  BioPlex,STRINGDB
LYPD6B
Tdark
Novelty:  0.1409054
p_int:  0.993710774
p_ni:  0.006289226
Data Source:  BioPlex
ELP2
Tbio
Novelty:  0.03034629
p_int:  0.992542946
p_ni:  0.007457054
Data Source:  BioPlex
SARS2
Tbio
Family:  Enzyme
Novelty:  0.00772323
p_int:  0.991974719
p_ni:  0.008025281
Score:  0.234
Data Source:  BioPlex,STRINGDB
TESPA1
Tbio
Novelty:  0.12779533
p_int:  0.981058585
p_ni:  0.018941408
p_wrong:  7e-9
Score:  0.179
Data Source:  BioPlex,STRINGDB
A1BG
Tbio
Novelty:  0.00508743
p_int:  0.980462808
p_ni:  0.019536927
p_wrong:  2.66e-7
Score:  0.532
Data Source:  BioPlex,STRINGDB
FSTL4
Tdark
Novelty:  0.29038823
p_int:  0.976065345
p_ni:  0.023934655
Score:  0.815
Data Source:  BioPlex,STRINGDB
Pathways (3)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Gene Ontology Terms (7)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cardiac troponin T measurement
1
1
1
26.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cardiac troponin T measurement
1
26.1
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium channel modulatory factor 1
VGNC:277
459357
Macaque
potassium channel modulatory factor 1
694645
Mouse
MGI:1921537
74287
Rat
RGD:1591490
684322
Dog
potassium channel modulatory factor 1 [Source:HGNC Symbol;Acc:HGNC:20589]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium channel modulatory factor 1
Macaque
potassium channel modulatory factor 1
Mouse
Rat
Dog
potassium channel modulatory factor 1 [Source:HGNC Symbol;Acc:HGNC:20589]
Publication Statistics
PubMed Score 18.04
PubMed score by year
PubTator Score 5.43
PubTator score by year