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Tbio
MRPL36
39S ribosomal protein L36, mitochondrial

Protein Summary
Description
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. A pseudogene corresponding to this gene is found on chromosome 2p. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000382647
  • ENSP00000372093
  • ENSG00000171421
  • ENST00000505059
  • ENSP00000423152
  • ENST00000505818
  • ENSP00000427152
  • ENST00000508987
  • ENSP00000423399

Symbol
  • BRIP1
  • RPMJ
  • BRIP1
  • L36mt
  • PRPL36
  • MRP-L36
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
small molecule perturbation
0.87
disease perturbation
0.79
transcription factor binding site profile
0.78
histone modification site profile
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.68   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 57   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.68   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
3
0
1.2
85.8
electrocardiography
1
1
30
31.4
joint damage measurement
1
1
1
3
response to TNF antagonist
1
1
1
3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
85.8
electrocardiography
30
31.4
joint damage measurement
1
3
response to TNF antagonist
1
3
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein L36
VGNC:4089
750868
Macaque
mitochondrial ribosomal protein L36
100430880
Mouse
MGI:2137228
94066
Dog
mitochondrial ribosomal protein L36
VGNC:43393
488065
Horse
mitochondrial ribosomal protein L36
VGNC:20337
100071885
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein L36
Macaque
mitochondrial ribosomal protein L36
Mouse
Dog
mitochondrial ribosomal protein L36
Horse
mitochondrial ribosomal protein L36
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9P0J6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Mitochondrial translation initiation
Reactome
Mitochondrial translation termination
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (247)
1 – 10 of 247
MRPS11
Tdark
Novelty:  0.29449255
Score:  0.999
Data Source:  STRINGDB
MRPS16
Tbio
Novelty:  0.24108603
Score:  0.999
Data Source:  STRINGDB
MRPL32
Tdark
Novelty:  0.58976136
Score:  0.999
Data Source:  STRINGDB
MRPL17
Tdark
Novelty:  1.20541719
Score:  0.999
Data Source:  STRINGDB
MRPL40
Tbio
Novelty:  0.09916967
Score:  0.999
Data Source:  STRINGDB
MRPL27
Tdark
Novelty:  0.15636105
Score:  0.999
Data Source:  STRINGDB
MRPL33
Tdark
Novelty:  0.49802524
Score:  0.998
Data Source:  STRINGDB
MRPL2
Tdark
Novelty:  1.01237797
Score:  0.998
Data Source:  STRINGDB
MRPL21
Tdark
Novelty:  0.56552559
Score:  0.998
Data Source:  STRINGDB
MRPS2
Tbio
Novelty:  0.14756204
Score:  0.998
Data Source:  STRINGDB
Publication Statistics
PubMed Score  33.68

PubMed score by year
PubTator Score  6.28

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer