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Tbio
PDP1
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

Protein Summary
Description
Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex. Pyruvate dehydrogenase (E1) is one of the three components (E1, E2, and E3) of the large pyruvate dehydrogenase complex. Pyruvate dehydrogenase kinases catalyze phosphorylation of serine residues of E1 to inactivate the E1 component and inhibit the complex. Pyruvate dehydrogenase phosphatases catalyze the dephosphorylation and activation of the E1 component to reverse the effects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenase phosphatase is a heterodimer consisting of catalytic and regulatory subunits. Two catalytic subunits have been reported; one is predominantly expressed in skeletal muscle and another one is is much more abundant in the liver. The catalytic subunit, encoded by this gene, is the former, and belongs to the protein phosphatase 2C (PP2C) superfamily. Along with the pyruvate dehydrogenase complex and pyruvate dehydrogena ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297598
  • ENSP00000297598
  • ENSG00000164951
  • ENST00000396200
  • ENSP00000379503
  • ENST00000517764
  • ENSP00000430380
  • ENST00000520728
  • ENSP00000428317

Symbol
  • PDP
  • PPM2C
  • PDH
  • PDP
  • PDPC
  • PPM2A
  • PPM2C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.88
histone modification site profile
0.86
transcription factor perturbation
0.8
transcription factor
0.72
tissue sample
0.69


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 182.03   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 249   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 182.03   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 249   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pyruvate dehyrogenase phosphatase catalytic subunit 1
VGNC:818
472819
Macaque
pyruvate dehyrogenase phosphatase catalytic subunit 1
699172
Mouse
MGI:2685870
381511
Rat
RGD:620393
54705
Dog
pyruvate dehyrogenase phosphatase catalytic subunit 1
VGNC:44388
477941
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pyruvate dehyrogenase phosphatase catalytic subunit 1
Macaque
pyruvate dehyrogenase phosphatase catalytic subunit 1
Mouse
Rat
Dog
pyruvate dehyrogenase phosphatase catalytic subunit 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9P0J1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Pyruvate metabolism
Reactome
Pyruvate metabolism and Citric Acid (TCA) cycle
Reactome
Regulation of pyruvate dehydrogenase (PDH) complex
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Metabolism
Pyruvate metabolism
Pyruvate metabolism and Citric Acid (TCA) cycle
Regulation of pyruvate dehydrogenase (PDH) complex
The citric acid (TCA) cycle and respiratory electron transport
Protein-Protein Interactions (86)
1 – 10 of 86
PDPR
Tbio
Family:  Enzyme
Novelty:  0.04223174
p_int:  0.999995132
p_ni:  0.000004868
Score:  0.953
Data Source:  BioPlex,Reactome,STRINGDB
LOX
Tchem
Family:  Enzyme
Novelty:  0.000273
p_int:  0.999965734
p_ni:  0.000034266
Data Source:  BioPlex
WRN
Tbio
Family:  Enzyme
Novelty:  0.00163164
p_int:  0.999955552
p_ni:  0.000044418
p_wrong:  3e-8
Data Source:  BioPlex
SDHA
Tbio
Family:  Enzyme
Novelty:  0.00223171
p_int:  0.999813995
p_ni:  0.000186005
Score:  0.297
Data Source:  BioPlex,STRINGDB
SPRED2
Tbio
Novelty:  0.04447225
p_int:  0.999788673
p_ni:  0.000211327
Score:  0.189
Data Source:  BioPlex,STRINGDB
MRPL37
Tdark
Novelty:  0.26004605
p_int:  0.999583003
p_ni:  0.000416997
Data Source:  BioPlex
SNUPN
Tbio
Novelty:  0.04456914
p_int:  0.999563548
p_ni:  0.000436452
Score:  0.29
Data Source:  BioPlex,STRINGDB
SAMD4B
Tbio
Novelty:  0.10461155
p_int:  0.998709582
p_ni:  0.001290418
Score:  0.769
Data Source:  BioPlex,STRINGDB
PNOC
Tbio
Novelty:  0.00132014
p_int:  0.998133718
p_ni:  0.001866263
p_wrong:  1.9e-8
Data Source:  BioPlex
ADIPOQ
Tbio
Novelty:  0.00011196
p_int:  0.994541252
p_ni:  0.005458658
p_wrong:  9e-8
Data Source:  BioPlex
Publication Statistics
PubMed Score  182.03

PubMed score by year
PubTator Score  483.31

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer