Tclin NDUFA13 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

Protein Summary

Description

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis (PubMed:27626371). Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (PubMed:27626371). Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes (PubMed:15753091). This gene encodes a subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain. The protein is required for complex I assembly and electron transfer activity. The protein binds the signal transducers and activators of transcription 3 (STAT3) transcription factor, and can function as a tumor suppressor. The human protein purified from mitochondria migrates at approximately 16 kDa. Transcripts originating from an upstream promoter and capable of expressing a protein with a longer N-terminus have been found, but their biological validity has not been determined. [provided by RefSeq, Oct 2009]

Uniprot Accession IDs

• Q9P0J0
• B4DF76
• K7EK58
• Q6PKI0
• Q9H2L3
• Q9Y327

Gene Name

• NDUFA13

Ensembl ID

• ENST00000507754
• ENSP00000423673
• ENSG00000186010

Symbol

• GRIM19
• B16.6
• CDA016
• CGI-39
• GRIM19
• GRIM-19
• MC1DN28

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.95
molecular function	0.91
histone modification site profile	0.87
transcription factor binding site profile	0.85
interacting protein	0.77

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Dehydrogenase / Nadh Dehydrogenase [Ubiquinone] 1 Alpha Subcomplex Subunit 13

DTO Classes

Protein / Enzyme / Oxidoreductase / Dehydrogenase / Nadh Dehydrogenase [Ubiquinone] 1 Alpha Subcomplex Subunit 13

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.69   (req: < 5)

Gene RIFs: 68   (req: <= 3)

Antibodies: 261   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.69   (req: >= 5)

Gene RIFs: 68   (req: > 3)

Antibodies: 261   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1