You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
NDUFA13
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

Protein Summary
Description
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis (PubMed:27626371). Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (PubMed:27626371). Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes (PubMed:15753091). This gene encodes a subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain. The protein is required for complex I assembly and electron transfer activity. The protein binds the signal transd ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000507754
  • ENSP00000423673
  • ENSG00000186010

Symbol
  • GRIM19
  • B16.6
  • CDA016
  • CGI-39
  • GRIM19
  • GRIM-19
  • MC1DN28
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.95
molecular function
0.91
histone modification site profile
0.87
transcription factor binding site profile
0.85
interacting protein
0.77


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.17   (req: < 5)
Gene RIFs: 60   (req: <= 3)
Antibodies: 261   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.17   (req: >= 5)
Gene RIFs: 60   (req: > 3)
Antibodies: 261   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
metformin
chemical structure image
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
1
1
82
platelet count
1
1
1
10.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
82
platelet count
1
10.7
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NADH:ubiquinone oxidoreductase subunit A13
VGNC:6639
455877
Mouse
MGI:1914434
67184
Rat
RGD:6492821
100911483
Dog
NADH:ubiquinone oxidoreductase subunit A13
VGNC:43686
476659
Horse
NADH:ubiquinone oxidoreductase subunit A13 [Source:HGNC Symbol;Acc:HGNC:17194]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NADH:ubiquinone oxidoreductase subunit A13
Mouse
Rat
Dog
NADH:ubiquinone oxidoreductase subunit A13
Horse
NADH:ubiquinone oxidoreductase subunit A13 [Source:HGNC Symbol;Acc:HGNC:17194]
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9P0J0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (18)
Complex I biogenesis (R-HSA-6799198)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complex I biogenesis
Reactome
Metabolism
Reactome
Respiratory electron transport
Reactome
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Complex I biogenesis
Metabolism
Respiratory electron transport
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
The citric acid (TCA) cycle and respiratory electron transport
Protein-Protein Interactions (160)
1 – 10 of 160
NDUFAF1
Tclin
Novelty: 0.05630549
p_int: 0.999821759
p_ni: 0.000178241
Score: 0.986
Data Source: BioPlex,STRINGDB
NDUFS4
Tclin
Family: Enzyme
Novelty: 0.00787292
p_int: 0.999542861
p_ni: 0.00041259
p_wrong: 0.000044549
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFB5
Tclin
Family: Enzyme
Novelty: 0.0257403
p_int: 0.998951296
p_ni: 0.001048704
Score: 0.998
Data Source: BioPlex,STRINGDB
NDUFV3
Tclin
Family: Enzyme
Novelty: 0.15352039
p_int: 0.997155484
p_ni: 0.002844517
Score: 0.995
Data Source: BioPlex,STRINGDB
ECSIT
Tbio
Novelty: 0.04690184
p_int: 0.995363144
p_ni: 0.004636856
Score: 0.987
Data Source: BioPlex,STRINGDB
NDUFC2
Tclin
Family: Enzyme
Novelty: 0.08387385
p_int: 0.995049109
p_ni: 0.004950877
p_wrong: 1.5e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFA12
Tclin
Family: Enzyme
Novelty: 0.04679316
p_int: 0.99353978
p_ni: 0.00646022
Score: 0.999
Data Source: BioPlex,STRINGDB
MT-ND4
Tclin
Family: Enzyme
Novelty: 0.00079935
p_int: 0.990137801
p_ni: 0.003959186
p_wrong: 0.005903013
Score: 0.997
Data Source: BioPlex,STRINGDB
CST1
Tbio
Novelty: 0.02399609
p_int: 0.989248143
p_ni: 0.010724679
p_wrong: 0.000027178
Data Source: BioPlex
CPT2
Tchem
Family: Enzyme
Novelty: 0.00345645
p_int: 0.987665933
p_ni: 0.012334067
Score: 0.362
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  70.17

PubMed score by year
PubTator Score  72.44

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: