You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
KLK14
Kallikrein-14

Protein Classes
Protein Summary
Description
Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface. May be involved in several aspects of tumor progression including growth, invasion and angiogenesis. This gene encodes a member of the kallikrein subfamily of serine proteases that have diverse physiological functions such as regulation of blood pressure and desquamation. The altered expression of this gene is implicated in the progression of different cancers including breast and prostate tumors. The encoded protein is a precursor that is proteolytically processed to generate t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000391802
  • ENSP00000375678
  • ENSG00000129437

Symbol
  • KLKL6
  • KLK-L6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.58
biological term
0.51
cell line
0.49
trait
0.46
cell type or tissue
0.44


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.71   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 193   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.71   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 193   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (4)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Formation of the cornified envelope
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Formation of the cornified envelope
Keratinization
Gene Ontology Terms (11)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (27)
1 – 10 of 27
GTPBP3
Tbio
Family: Enzyme
Novelty: 0.13422819
p_int: 0.874260627
p_ni: 0.125739373
Data Source: BioPlex
CNNM4
Tbio
Novelty: 0.05575181
p_int: 0.787563763
p_ni: 0.212436237
Data Source: BioPlex
SPINK6
Tbio
Family: Enzyme
Novelty: 0.15195369
Score: 0.968
Data Source: Reactome,STRINGDB
SPINK5
Tbio
Family: Enzyme
Novelty: 0.00033689
Score: 0.836
Data Source: STRINGDB
SIGLEC9
Tbio
Novelty: 0.02304766
Score: 0.8
Data Source: STRINGDB
CDSN
Tbio
Novelty: 0.0147621
Score: 0.677
Data Source: STRINGDB
KNG1
Tchem
Novelty: 0.00008572
Score: 0.668
Data Source: STRINGDB
SIGLEC7
Tbio
Novelty: 0.02043706
Score: 0.648
Data Source: STRINGDB
TGM4
Tbio
Family: Enzyme
Novelty: 0.00399816
Score: 0.641
Data Source: STRINGDB
SPINK9
Tbio
Family: Enzyme
Novelty: 0.39510818
Score: 0.569
Data Source: STRINGDB
Publication Statistics
PubMed Score  39.71

PubMed score by year
PubTator Score  33.15

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: