Tbio HACD3 Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3

Protein Summary

Description

Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May be involved in Rac1-signaling pathways leading to the modulation of gene expression. Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571).

Uniprot Accession IDs

• Q9P035
• A0PJA1
• B4DRF4
• Q280Z3
• Q6PD63
• Q8IUI5
• Q8NC86
• Q8NCB1
• Q96T12
• Q9NQA7

Gene Name

• HACD3

Ensembl ID

• ENST00000261875
• ENSP00000261875
• ENSG00000074696
• ENST00000442729
• ENSP00000392491

Symbol

• BIND1
• PTPLAD1
• BIND1
• B-IND1
• HSPC121
• PTPLAD1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
transcription factor perturbation	0.94
kinase perturbation	0.84
disease perturbation	0.83
ligand (protein) perturbation	0.83

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.81   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 107   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.81   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0