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Tclin
NDUFAF4
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4

Protein Summary
Description
Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). May be involved in cell proliferation and survival of hormone-dependent tumor cells. May be a regulator of breast tumor cell invasion. NADH:ubiquinone oxidoreductase (complex I) catalyzes the transfer of electrons from NADH to ubiquinone (coenzyme Q) in the first step of the mitochondrial respiratory chain, resulting in the translocation of protons across the inner mitochondrial membrane. This gene encodes a complex I assembly factor. Mutations in this gene are a cause of mitochondrial complex I deficiency. [provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316149
  • ENSP00000358272
  • ENSG00000123545

Symbol
  • C6orf66
  • HRPAP20
  • My013
  • C6orf66
  • HRPAP20
  • HSPC125
  • MC1DN15
  • bA22L21.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
histone modification site profile
0.85
transcription factor binding site profile
0.81
transcription factor perturbation
0.74
tissue sample
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.91   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 115   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.91   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 115   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
metformin
Rendered image for metformin
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
62.5
mathematical ability
2
1
2
57.3
cognitive function measurement
1
1
1
46.5
body mass index
2
2
3
42.2
waist-hip ratio
2
1
2
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
62.5
mathematical ability
2
57.3
cognitive function measurement
1
46.5
body mass index
3
42.2
waist-hip ratio
2
31.4
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NADH:ubiquinone oxidoreductase complex assembly factor 4
VGNC:8172
735873
Macaque
NADH:ubiquinone oxidoreductase complex assembly factor 4
705102
Mouse
MGI:1915743
68493
Rat
Dog
NADH:ubiquinone oxidoreductase complex assembly factor 4
VGNC:43694
475001
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NADH:ubiquinone oxidoreductase complex assembly factor 4
Macaque
NADH:ubiquinone oxidoreductase complex assembly factor 4
Mouse
Rat
Dog
NADH:ubiquinone oxidoreductase complex assembly factor 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9P032-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Complex I biogenesis (R-HSA-6799198)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complex I biogenesis
Reactome
Metabolism
Reactome
Respiratory electron transport
Reactome
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Complex I biogenesis
Metabolism
Respiratory electron transport
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
The citric acid (TCA) cycle and respiratory electron transport
Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (98)
1 – 10 of 98
NDUFS8
Tclin
Family:  Enzyme
Novelty:  0.02408724
p_int:  0.999853928
p_ni:  0.000146072
Score:  0.964
Data Source:  BioPlex,STRINGDB
NDUFAF1
Tclin
Novelty:  0.05630549
p_int:  0.999819154
p_ni:  0.000180846
Score:  0.983
Data Source:  BioPlex,STRINGDB
NDUFAF3
Tclin
Family:  Enzyme
Novelty:  0.00063584
p_int:  0.999402323
p_ni:  0.000597677
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
NDUFB5
Tclin
Family:  Enzyme
Novelty:  0.0257403
p_int:  0.997454084
p_ni:  0.002545911
p_wrong:  6e-9
Score:  0.92
Data Source:  BioPlex,STRINGDB
NDUFS2
Tclin
Family:  Enzyme
Novelty:  0.02347576
p_int:  0.997353677
p_ni:  0.002646323
Score:  0.971
Data Source:  BioPlex,STRINGDB
NDUFAF5
Tbio
Family:  Enzyme
Novelty:  0.13483499
p_int:  0.997052394
p_ni:  0.002947535
p_wrong:  7.1e-8
Score:  0.981
Data Source:  BioPlex,Reactome,STRINGDB
TMEM126B
Tbio
Novelty:  0.21278172
p_int:  0.994432807
p_ni:  0.005567172
p_wrong:  2.2e-8
Score:  0.948
Data Source:  BioPlex,STRINGDB
MT-ND4
Tclin
Family:  Enzyme
Novelty:  0.00079935
p_int:  0.994295484
p_ni:  0.005533108
p_wrong:  0.000171407
Score:  0.935
Data Source:  BioPlex,Reactome,STRINGDB
NDUFC2
Tclin
Family:  Enzyme
Novelty:  0.08387385
p_int:  0.991506183
p_ni:  0.00849373
p_wrong:  8.7e-8
Score:  0.926
Data Source:  BioPlex,STRINGDB
NDUFS3
Tclin
Family:  Enzyme
Novelty:  0.01968313
p_int:  0.985585571
p_ni:  0.01441443
Score:  0.988
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  9.91

PubMed score by year
PubTator Score  5.64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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