CRIPT
Cysteine-rich PDZ-binding protein
Protein Summary
Involved in the cytoskeletal anchoring of DLG4 in excitatory synapses. This gene encodes a protein that binds to the PDZ3 peptide recognition domain. The encoded protein may modulates protein interactions with the cytoskeleton. A mutation in this gene resulted in short stature with microcephaly and distinctive facies. [provided by RefSeq, Jun 2014]
- ENST00000238892
- ENSP00000238892
- ENSG00000119878
- SSMDF
- HSPC139
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.91 | ||
transcription factor perturbation | 0.74 | ||
transcription factor binding site profile | 0.69 | ||
kinase perturbation | 0.66 | ||
microRNA | 0.65 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 24.89 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 89 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 24.89 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 89 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (26)
TAX1BP3
Novelty: 0.01605171
p_int: 0.834222775
p_ni: 0.000024448
p_wrong: 0.165752776
Score: 0.21
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (18)
Functions (4)
Components (10)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
gait measurement | 1 | 1 | 1 | 17.8 | |||||
body height | 1 | 1 | 1 | 13.3 | |||||
parental genotype effect measurement | 1 | 1 | 1 | 6.8 | |||||
birth weight | 1 | 1 | 1 | 6.8 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
gait measurement | 1 | 17.8 | |||||
body height | 1 | 13.3 | |||||
parental genotype effect measurement | 1 | 6.8 | |||||
birth weight | 1 | 6.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | CXXC repeat containing interactor of PDZ3 domain | VGNC:211 | 459208 | |||||
Macaque | CXXC repeat containing interactor of PDZ3 domain | 714949 | ||||||
Mouse | MGI:1929655 | 56724 | ||||||
Rat | RGD:621545 | 56725 | ||||||
Dog | CXXC repeat containing interactor of PDZ3 domain | VGNC:39615 | 609976 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | CXXC repeat containing interactor of PDZ3 domain | |||||
Macaque | CXXC repeat containing interactor of PDZ3 domain | |||||
Mouse | ||||||
Rat | ||||||
Dog | CXXC repeat containing interactor of PDZ3 domain | |||||
Publication Statistics
PubMed Score 24.89
PubMed score by year
PubTator Score 8.05
PubTator score by year
Related Publications
Text Mined References (19)
GeneRif Annotations (2)
Items per page:
0 of 0
PMID | Year | Title |
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