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Tbio
CRIPT
Cysteine-rich PDZ-binding protein

Protein Summary
Description
Involved in the cytoskeletal anchoring of DLG4 in excitatory synapses. This gene encodes a protein that binds to the PDZ3 peptide recognition domain. The encoded protein may modulates protein interactions with the cytoskeleton. A mutation in this gene resulted in short stature with microcephaly and distinctive facies. [provided by RefSeq, Jun 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000238892
  • ENSP00000238892
  • ENSG00000119878

Symbol
  • SSMDF
  • HSPC139
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
transcription factor perturbation
0.74
transcription factor binding site profile
0.69
kinase perturbation
0.66
microRNA
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.89   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 89   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.89   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 89   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (26)
TAX1BP3
Tbio
Novelty:  0.01605171
p_int:  0.834222775
p_ni:  0.000024448
p_wrong:  0.165752776
Score:  0.21
Data Source:  BioPlex,STRINGDB
DLG4
Tchem
Novelty:  0.00057285
Score:  0.793
Data Source:  STRINGDB
DLG1
Tbio
Novelty:  0.0050926
Score:  0.747
Data Source:  STRINGDB
DLG3
Tbio
Novelty:  0.01196565
Score:  0.706
Data Source:  STRINGDB
TRAM1
Tbio
Novelty:  0.17795822
Score:  0.667
Data Source:  STRINGDB
DLG2
Tbio
Novelty:  0.00999909
Score:  0.634
Data Source:  STRINGDB
MRPL45
Tdark
Novelty:  0.42464896
Score:  0.601
Data Source:  STRINGDB
TTC7A
Tbio
Novelty:  0.0282236
Score:  0.592
Data Source:  STRINGDB
GPATCH11
Tdark
Novelty:  0.86338046
Score:  0.577
Data Source:  STRINGDB
MCFD2
Tbio
Novelty:  0.0402944
Score:  0.57
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gait measurement
1
1
1
17.8
body height
1
1
1
13.3
parental genotype effect measurement
1
1
1
6.8
birth weight
1
1
1
6.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gait measurement
1
17.8
body height
1
13.3
parental genotype effect measurement
1
6.8
birth weight
1
6.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CXXC repeat containing interactor of PDZ3 domain
VGNC:211
459208
Macaque
CXXC repeat containing interactor of PDZ3 domain
714949
Mouse
MGI:1929655
56724
Rat
RGD:621545
56725
Dog
CXXC repeat containing interactor of PDZ3 domain
VGNC:39615
609976
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CXXC repeat containing interactor of PDZ3 domain
Macaque
CXXC repeat containing interactor of PDZ3 domain
Mouse
Rat
Dog
CXXC repeat containing interactor of PDZ3 domain
Publication Statistics
PubMed Score 24.89
PubMed score by year
PubTator Score 8.05
PubTator score by year
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Related Publications
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PMID
Year
Title