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Tbio
CWC15
Spliceosome-associated protein CWC15 homolog

Protein Summary
Description
Involved in pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:28076346). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000279839
  • ENSP00000475615
  • ENSG00000150316

Symbol
  • C11orf5
  • ORF5
  • AD002
  • Cwf15
  • C11orf5
  • HSPC148
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.93
histone modification site profile
0.89
tissue
0.68
tissue sample
0.66
transcription factor binding site profile
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 516.57   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 69   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 516.57   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (273)
CTNNBL1
Tbio
Novelty:  0.0189038
p_int:  0.999973582
p_ni:  0.000026418
Score:  0.999
Data Source:  BioPlex,STRINGDB
SIRT5
Tchem
Family:  Epigenetic
Novelty:  0.00225239
p_int:  0.980725255
p_ni:  0.015452009
p_wrong:  0.003822736
Score:  0.455
Data Source:  BioPlex,STRINGDB
SIRT1
Tchem
Family:  Epigenetic
Novelty:  0.00022265
p_int:  0.959811907
p_ni:  0.040188093
Score:  0.21
Data Source:  BioPlex,STRINGDB
BCAS2
Tbio
Novelty:  0.05425016
Score:  0.999
Data Source:  STRINGDB
PRPF19
Tbio
Novelty:  0.01616737
Score:  0.999
Data Source:  STRINGDB
CDC5L
Tbio
Family:  TF
Novelty:  0.00663599
Score:  0.999
Data Source:  STRINGDB
PLRG1
Tbio
Novelty:  0.05163655
Score:  0.999
Data Source:  STRINGDB
HSPA8
Tchem
Novelty:  0.00081014
Score:  0.999
Data Source:  STRINGDB
PRPF8
Tbio
Novelty:  0.01717158
Score:  0.998
Data Source:  STRINGDB
SNW1
Tbio
Novelty:  0.01423797
Score:  0.998
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Metabolism of RNA (R-HSA-8953854)

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Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
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Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1913320
66070
Rat
RGD:1310669
300361
Dog
CWC15 spliceosome associated protein homolog
476768
Cow
CWC15 spliceosome associated protein homolog
535258
Platypus
spliceosome-associated protein CWC15 homolog
100082990
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
CWC15 spliceosome associated protein homolog
Cow
CWC15 spliceosome associated protein homolog
Platypus
spliceosome-associated protein CWC15 homolog
Publication Statistics
PubMed Score 516.57
PubMed score by year
PubTator Score 138.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title