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Tbio
CNIH4
Protein cornichon homolog 4

Protein Summary
Description
Involved in G protein-coupled receptors (GPCRs) trafficking from the endoplasmic reticulum to the cell surface; it promotes the exit of GPCRs from the early secretory pathway, likely through interaction with the COPII machinery (PubMed:24405750).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366857
  • ENSP00000355822
  • ENSG00000143771
  • ENST00000465271
  • ENSP00000420443

Symbol
  • CNIH2
  • CNIH-4
  • HSPC163
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
kinase perturbation
0.81
virus perturbation
0.79
disease perturbation
0.74
transcription factor binding site profile
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.07   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 65   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.07   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 65   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
58.7
reticulocyte measurement
2
1
2
32.6
apolipoprotein A 1 measurement
1
1
1
30.6
high density lipoprotein cholesterol measurement
1
1
1
20.1
reticulocyte count
2
1
2
18.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
58.7
reticulocyte measurement
2
32.6
apolipoprotein A 1 measurement
1
30.6
high density lipoprotein cholesterol measurement
1
20.1
reticulocyte count
2
18.8
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cornichon family AMPA receptor auxiliary protein 4
VGNC:506
736006
Macaque
cornichon family AMPA receptor auxiliary protein 4
701767
Mouse
MGI:1925828
98417
Rat
RGD:1559740
289324
Dog
cornichon family AMPA receptor auxiliary protein 4
VGNC:39402
480116
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cornichon family AMPA receptor auxiliary protein 4
Macaque
cornichon family AMPA receptor auxiliary protein 4
Mouse
Rat
Dog
cornichon family AMPA receptor auxiliary protein 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9P003-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (44)
1 – 10 of 44
PACSIN3
Tbio
Family: Enzyme
Novelty: 0.11715903
Score: 0.705
Data Source: STRINGDB
NT5C1A
Tbio
Family: Enzyme
Novelty: 0.00634411
Score: 0.64
Data Source: STRINGDB
SGMS1
Tchem
Family: Enzyme
Novelty: 0.01717229
Score: 0.63
Data Source: STRINGDB
STX7
Tbio
Novelty: 0.03109969
Score: 0.625
Data Source: STRINGDB
SURF4
Tbio
Novelty: 0.03230108
Score: 0.614
Data Source: STRINGDB
SEC24B
Tbio
Novelty: 0.01031644
Score: 0.604
Data Source: STRINGDB
WDR26
Tbio
Novelty: 0.04140166
Score: 0.584
Data Source: STRINGDB
KLHL18
Tdark
Novelty: 0.52915213
Score: 0.547
Data Source: STRINGDB
PDE7A
Tclin
Family: Enzyme
Novelty: 0.00872596
Score: 0.543
Data Source: STRINGDB
FBXO28
Tbio
Novelty: 0.10548865
Score: 0.536
Data Source: STRINGDB
Publication Statistics
PubMed Score  2.07

PubMed score by year
PubTator Score  1.59

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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