Tdark COMMD9 COMM domain-containing protein 9

Protein Summary

Description

May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966). Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits (PubMed:23637203).

Uniprot Accession IDs

• Q9P000
• E9PAN2
• Q96FI2
• Q9H0R0

Gene Name

• COMMD9

Ensembl ID

• ENST00000263401
• ENSP00000263401
• ENSG00000110442
• ENST00000452374
• ENSP00000392510

Symbol

• HSPC166
• C11orf55
• LINC00610

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.95
kinase perturbation	0.91
histone modification site profile	0.81
transcription factor perturbation	0.8
transcription factor binding site profile	0.77

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.24   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 139   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.24   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0