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Tdark
COMMD9
COMM domain-containing protein 9

Protein Summary
Description
May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966). Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits (PubMed:23637203).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263401
  • ENSP00000263401
  • ENSG00000110442
  • ENST00000452374
  • ENSP00000392510

Symbol
  • HSPC166
  • C11orf55
  • LINC00610
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
kinase perturbation
0.91
histone modification site profile
0.81
transcription factor perturbation
0.8
transcription factor binding site profile
0.77


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.02   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 139   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.02   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
3
6
6
84.7
waist-hip ratio
1
4
4
83.3
3
3
0
1
68.3
childhood onset asthma
1
1
0
1.1
57.8
BMI-adjusted waist circumference
1
2
2
45.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
6
84.7
waist-hip ratio
4
83.3
0
1
68.3
childhood onset asthma
0
1.1
57.8
BMI-adjusted waist circumference
2
45.6
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
COMM domain containing 9
716992
Mouse
MGI:1923751
76501
Rat
RGD:1307706
295956
Dog
COMM domain containing 9
VGNC:39499
608575
Horse
COMM domain containing 9
VGNC:16764
100052172
Species
Name
OMA
EggNOG
Inparanoid
Macaque
COMM domain containing 9
Mouse
Rat
Dog
COMM domain containing 9
Horse
COMM domain containing 9
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9P000-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism of proteins
Reactome
Neddylation
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Metabolism of proteins
Neddylation
Neutrophil degranulation
Protein-Protein Interactions (201)
1 – 10 of 201
COMMD8
Tdark
Novelty:  0.33240242
p_int:  0.999999672
p_ni:  2.79e-7
p_wrong:  4.9e-8
Score:  0.992
Data Source:  BioPlex,STRINGDB
COMMD4
Tbio
Novelty:  0.20453574
p_int:  0.999999586
p_ni:  4.14e-7
Score:  0.994
Data Source:  BioPlex,STRINGDB
COMMD10
Tbio
Novelty:  0.29057641
p_int:  0.999997833
p_ni:  0.000002167
Score:  0.995
Data Source:  BioPlex,STRINGDB
CCDC22
Tbio
Novelty:  0.01400901
p_int:  0.999997086
p_ni:  0.000002914
Score:  0.994
Data Source:  BioPlex,STRINGDB
COMMD3
Tbio
Novelty:  0.07399068
p_int:  0.99999678
p_ni:  0.00000322
Score:  0.995
Data Source:  BioPlex,STRINGDB
COMMD1
Tbio
Novelty:  0.01349432
p_int:  0.999996335
p_ni:  0.000003647
p_wrong:  1.8e-8
Score:  0.992
Data Source:  BioPlex,STRINGDB
FAM45A
Tdark
Novelty:  0.94034891
p_int:  0.999993872
p_ni:  0.000006128
Score:  0.869
Data Source:  BioPlex,STRINGDB
COMMD6
Tbio
Novelty:  0.11854363
p_int:  0.999991645
p_ni:  0.000008353
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
COMMD2
Tdark
Novelty:  0.62195903
p_int:  0.999988748
p_ni:  0.000011252
Score:  0.994
Data Source:  BioPlex,STRINGDB
VPS29
Tbio
Novelty:  0.01335106
p_int:  0.999985296
p_ni:  0.000014704
Score:  0.85
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  2.02

PubMed score by year
PubTator Score  0.48

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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