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Tbio
CHMP5
Charged multivesicular body protein 5

Protein Summary
Description
Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane f ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000223500
  • ENSP00000223500
  • ENSG00000086065
  • ENST00000419016
  • ENSP00000442725

Symbol
  • C9orf83
  • SNF7DC2
  • Vps60
  • CGI-34
  • PNAS-2
  • C9orf83
  • HSPC177
  • SNF7DC2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.87
histone modification site profile
0.87
cell type or tissue
0.8
transcription factor binding site profile
0.78
interacting protein
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.31   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 210   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.31   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 210   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (11)
Budding and maturation of HIV virion (R-HSA-162588)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Budding and maturation of HIV virion
Reactome
Disease
Reactome
Endosomal Sorting Complex Required For Transport (ESCRT)
Reactome
HIV Infection
Reactome
HIV Life Cycle
Name
Explore in Pharos
Explore in Source
Budding and maturation of HIV virion
Disease
Endosomal Sorting Complex Required For Transport (ESCRT)
HIV Infection
HIV Life Cycle
Gene Ontology Terms (21)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Protein-Protein Interactions (126)
1 – 10 of 126
VTA1
Tbio
Novelty: 0.02244131
p_int: 0.999999994
p_ni: 6e-9
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
TCP10L
Tbio
Novelty: 0.26666667
p_int: 0.999996123
p_ni: 5.2e-8
p_wrong: 0.000003825
Score: 0.258
Data Source: BioPlex,STRINGDB
STMN4
Tbio
Novelty: 0.00798494
p_int: 0.999731209
p_ni: 2.4e-7
p_wrong: 0.00026855
Score: 0.798
Data Source: BioPlex,STRINGDB
CHMP1A
Tbio
Novelty: 0.06086208
p_int: 0.99791663
p_ni: 0.002083271
p_wrong: 1e-7
Score: 0.956
Data Source: BioPlex,STRINGDB
CHMP3
Tbio
Novelty: 0.02751272
p_int: 0.98949588
p_ni: 0.010503826
p_wrong: 2.94e-7
Score: 0.944
Data Source: BioPlex,STRINGDB
SH3KBP1
Tbio
Family: Enzyme
Novelty: 0.01467085
p_int: 0.98077149
p_ni: 0.01922851
Score: 0.522
Data Source: BioPlex,STRINGDB
CHMP2A
Tbio
Novelty: 0.00337804
p_int: 0.953081705
p_ni: 0.046918295
Score: 0.998
Data Source: BioPlex,STRINGDB
VPS4B
Tbio
Novelty: 0.00983426
Score: 0.994
Data Source: Reactome,STRINGDB
CHMP6
Tbio
Novelty: 0.0478065
Score: 0.992
Data Source: STRINGDB
CHMP4C
Tbio
Novelty: 0.1149268
Score: 0.992
Data Source: STRINGDB
Publication Statistics
PubMed Score  26.31

PubMed score by year
PubTator Score  15.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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