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Tbio
SELENON
Selenoprotein N

Protein Summary
Description
Isoform 2: Plays an important role in cell protection against oxidative stress and in the regulation of redox-related calcium homeostasis. Regulates the calcium level of the ER by protecting the calcium pump ATP2A2 against the oxidoreductase ERO1A-mediated oxidative damage. Within the ER, ERO1A activity increases the concentration of H(2)O(2), which attacks the luminal thiols in ATP2A2 and thus leads to cysteinyl sulfenic acid formation (-SOH) and SEPN1 reduces the SOH back to free thiol (-SH), thus restoring ATP2A2 activity (PubMed:25452428). Acts as a modulator of ryanodine receptor (RyR) activity: protects RyR from oxidation due to increased oxidative stress, or directly controls the RyR redox state, regulating the RyR-mediated calcium mobilization required for normal muscle development and differentiation (PubMed:19557870, PubMed:18713863). Essential for muscle regeneration and satellite cell maintenance in skeletal muscle (PubMed:21131290). This gene encodes a glycoprotein that is ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361547
  • ENSP00000355141
  • ENSG00000162430
  • ENST00000374315
  • ENSP00000363434

Symbol
  • SELN
  • SEPN1
  • RSS
  • CFTD
  • SELN
  • MDRS1
  • RSMD1
  • SEPN1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.16   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 134   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.16   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
selenoprotein N
VGNC:14525
456649
Mouse
MGI:2151208
74777
Rat
RGD:1304574
362624
Cow
selenoprotein N
616379
Opossum
selenoprotein N-like
100014552
Species
Name
OMA
EggNOG
Inparanoid
Chimp
selenoprotein N
Mouse
Rat
Cow
selenoprotein N
Opossum
selenoprotein N-like
Pathways (11)
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Selenium Micronutrient Network
WikiPathways
Selenium Micronutrient Network
WikiPathways
Selenium Micronutrient Network
WikiPathways
Selenium Micronutrient Network
WikiPathways
Selenium Metabolism and Selenoproteins
Name
Explore in Pharos
Explore in Source
Selenium Micronutrient Network
Selenium Micronutrient Network
Selenium Micronutrient Network
Selenium Micronutrient Network
Selenium Metabolism and Selenoproteins
Gene Ontology Terms (17)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (96)
1 – 10 of 96
PEX19
Tbio
Novelty: 0.00605342
p_int: 0.999091232
p_ni: 0.000908768
Data Source: BioPlex
PSCA
Tbio
Novelty: 0.00323778
p_int: 0.99812863
p_ni: 0.001871369
Data Source: BioPlex
WDR5B
Tdark
Novelty: 1.29746249
p_int: 0.993709767
p_ni: 0.006290233
Score: 0.181
Data Source: BioPlex,STRINGDB
SCGB2A2
Tbio
Novelty: 0.01594053
p_int: 0.990591551
p_ni: 0.009408449
p_wrong: 1e-9
Data Source: BioPlex
LYZL2
Tdark
Family: Enzyme
Novelty: 0.50542161
p_int: 0.97850635
p_ni: 0.02149365
Data Source: BioPlex
OS9
Tbio
Novelty: 0.01490339
p_int: 0.966973188
p_ni: 0.033025719
p_wrong: 0.000001094
Data Source: BioPlex
ARL2BP
Tbio
Novelty: 0.03460574
p_int: 0.9566088
p_ni: 0.043391199
p_wrong: 2e-9
Data Source: BioPlex
FEZ1
Tbio
Novelty: 0.02695814
p_int: 0.953667198
p_ni: 0.046332802
Data Source: BioPlex
HLA-DRB3
Tchem
p_int: 0.93744729
p_ni: 0.06255271
Data Source: BioPlex
PBXIP1
Tbio
Novelty: 0.15404864
p_int: 0.929250529
p_ni: 0.064687325
p_wrong: 0.006062145
Data Source: BioPlex
Publication Statistics
PubMed Score  102.16

PubMed score by year
PubTator Score  69.72

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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