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Tbio
CABP1
Calcium-binding protein 1

Protein Summary
Description
Modulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors (ITPRs)(PubMed:14570872). Inhibits agonist-induced intracellular calcium signaling (PubMed:15980432). Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels (PubMed:11865310). Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but has an opposite effect on channel function (PubMed:15140941). Suppresses the calcium-dependent inactivation of CACNA1D (By similarity). Inhibits TRPC5 channels (PubMed:15895247). Prevents NMDA receptor-induced cellular degeneration. Required for the normal transfer of light signals through the retina (By similarity). Calcium binding proteins are an important component of calcium mediated cellular signal transduction. This gene encodes a protein that belongs to a subfamily of calcium binding proteins ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000288616
  • ENSP00000288616
  • ENSG00000157782
  • ENST00000316803
  • ENSP00000317310
  • ENST00000351200
  • ENSP00000288615

Symbol
  • CALBRAIN
  • HCALB_BR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.92
molecular function
0.84
transcription factor
0.77
transcription factor binding site profile
0.73
PubMedID
0.58


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.42   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 114   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.42   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 114   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (71)
USP4
Tchem
Family:  Enzyme
Novelty:  0.01101075
p_int:  0.999801314
p_ni:  0.000198686
Score:  0.318
Data Source:  BioPlex,STRINGDB
CACNA1A
Tchem
Family:  IC
Novelty:  0.00069217
Score:  0.772
Data Source:  STRINGDB
CACNA1C
Tclin
Family:  IC
Novelty:  0.00099998
Score:  0.767
Data Source:  STRINGDB
HPCA
Tbio
Novelty:  0.01360155
Score:  0.712
Data Source:  STRINGDB
GRK5
Tchem
Family:  Kinase
Novelty:  0.01108012
Score:  0.672
Data Source:  STRINGDB
CIB1
Tchem
Novelty:  0.00364869
Score:  0.652
Data Source:  STRINGDB
ITPR1
Tchem
Family:  IC
Novelty:  0.00111834
Score:  0.635
Data Source:  STRINGDB
MYH10
Tchem
Novelty:  0.00624251
Score:  0.634
Data Source:  STRINGDB
ITPR3
Tchem
Family:  IC
Novelty:  0.00154917
Score:  0.631
Data Source:  STRINGDB
MYO1E
Tbio
Novelty:  0.01506519
Score:  0.626
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (35)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metabolite measurement
4
5
5
99.7
serum metabolite measurement
5
4
5
1.1
99.1
carnitine measurement
3
3
1
51.4
97.1
urinary metabolite measurement
3
3
3
96.6
C-reactive protein measurement
2
13
14
95.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metabolite measurement
5
99.7
serum metabolite measurement
5
1.1
99.1
carnitine measurement
1
51.4
97.1
urinary metabolite measurement
3
96.6
C-reactive protein measurement
14
95.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
calcium binding protein 1
VGNC:12856
452310
Macaque
calcium-binding protein 1
697825
Mouse
MGI:1352750
29867
Rat
RGD:620385
171051
Horse
calcium binding protein 1
VGNC:15975
100050122
Species
Name
OMA
EggNOG
Inparanoid
Chimp
calcium binding protein 1
Macaque
calcium-binding protein 1
Mouse
Rat
Horse
calcium binding protein 1
Publication Statistics
PubMed Score 56.42
PubMed score by year
PubTator Score 30.49
PubTator score by year
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Related Publications
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PMID
Year
Title