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Tdark
FLRT1
Leucine-rich repeat transmembrane protein FLRT1

Protein Summary
Description
Plays a role in fibroblast growth factor-mediated signaling cascades that lead to the activation of MAP kinases. Promotes neurite outgrowth via FGFR1-mediated activation of downstream MAP kinases. Promotes an increase both in neurite number and in neurite length. May play a role in cell-cell adhesion and cell guidance via its interaction with ADGRL1/LPHN1 and ADGRL3. This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. The family members may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. The encoded protein shares sequence similarity with two other family members, FLRT2 and FLRT3. This gene is expressed in kidney and brain. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000246841
  • ENSP00000246841
  • ENSG00000126500

Symbol
  • SPG68
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
tissue sample
0.58
PubMedID
0.57
cell type or tissue
0.51
cell line
0.48


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.57   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 129   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.57   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 129   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (27)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
uric acid measurement
1
3
3
97.7
BMI-adjusted waist-hip ratio
3
13
15
96.5
urate measurement
3
7
8
94.9
waist-hip ratio
1
11
11
94.2
reticulocyte measurement
2
2
3
91.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
uric acid measurement
3
97.7
BMI-adjusted waist-hip ratio
15
96.5
urate measurement
8
94.9
waist-hip ratio
11
94.2
reticulocyte measurement
3
91.3
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fibronectin leucine rich transmembrane protein 1
VGNC:11779
742718
Macaque
fibronectin leucine rich transmembrane protein 1
717942
Mouse
MGI:3026647
396184
Rat
RGD:1565152
499308
Dog
fibronectin leucine rich transmembrane protein 1
VGNC:40904
483767
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fibronectin leucine rich transmembrane protein 1
Macaque
fibronectin leucine rich transmembrane protein 1
Mouse
Rat
Dog
fibronectin leucine rich transmembrane protein 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NZU1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Downstream signaling of activated FGFR1 (R-HSA-5654687)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Downstream signaling of activated FGFR1
Reactome
Signal Transduction
Reactome
Signaling by FGFR
Reactome
Signaling by FGFR1
Reactome
Signaling by Receptor Tyrosine Kinases
Name
Explore in Pharos
Explore in Source
Downstream signaling of activated FGFR1
Signal Transduction
Signaling by FGFR
Signaling by FGFR1
Signaling by Receptor Tyrosine Kinases
Gene Ontology Terms (19)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (54)
1 – 10 of 54
ADGRL3
Tbio
Family:  GPCR
Novelty:  0.00268343
p_int:  0.999999966
p_ni:  3.2e-8
p_wrong:  2e-9
Score:  0.83
Data Source:  BioPlex,STRINGDB
FLRT3
Tbio
Novelty:  0.05467656
p_int:  0.999993227
p_ni:  1e-9
p_wrong:  0.000006772
Score:  0.37
Data Source:  BioPlex,STRINGDB
RADIL
Tbio
Novelty:  0.08747353
p_int:  0.999957918
p_ni:  0.000041995
p_wrong:  8.7e-8
Score:  0.249
Data Source:  BioPlex,STRINGDB
PCDH17
Tbio
Novelty:  0.03341603
p_int:  0.999807679
p_ni:  0.000188131
p_wrong:  0.00000419
Score:  0.347
Data Source:  BioPlex,STRINGDB
ADGRL1
Tbio
Family:  GPCR
Novelty:  0.00957739
p_int:  0.999487427
p_ni:  0.000512573
Score:  0.851
Data Source:  BioPlex,STRINGDB
PCDHGC3
Tbio
Novelty:  0.07203024
p_int:  0.998423337
p_ni:  0.001576662
Score:  0.151
Data Source:  BioPlex,STRINGDB
PIK3CA
Tclin
Family:  Kinase
Novelty:  0.00044273
p_int:  0.998205284
p_ni:  0.001794713
p_wrong:  2e-9
Score:  0.318
Data Source:  BioPlex,STRINGDB
BLZF1
Tbio
Novelty:  0.04344183
p_int:  0.997318585
p_ni:  0.002676784
p_wrong:  0.000004631
Score:  0.175
Data Source:  BioPlex,STRINGDB
TCAF2
Tbio
Family:  Enzyme
Novelty:  0.37070492
p_int:  0.996057429
p_ni:  0.003941408
p_wrong:  0.000001163
Data Source:  BioPlex
PCDH7
Tbio
Novelty:  0.04017185
p_int:  0.991796407
p_ni:  0.008203593
Data Source:  BioPlex
Publication Statistics
PubMed Score  4.57

PubMed score by year
PubTator Score  2

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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