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Tbio
CALML5
Calmodulin-like protein 5

Protein Summary
Description
Binds calcium. May be involved in terminal differentiation of keratinocytes. This gene encodes a novel calcium binding protein expressed in the epidermis and related to the calmodulin family of calcium binding proteins. Functional studies with recombinant protein demonstrate it does bind calcium and undergoes a conformational change when it does so. Abundant expression is detected only in reconstructed epidermis and is restricted to differentiating keratinocytes. In addition, it can associate with transglutaminase 3, shown to be a key enzyme in the terminal differentiation of keratinocytes. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380332
  • ENSP00000369689
  • ENSG00000178372

Symbol
  • CLSP
  • CLSP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.97
protein complex
0.76
tissue sample
0.6
disease perturbation
0.56
virus perturbation
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.98   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 168   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.98   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 168   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (45)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Gene Ontology Terms (10)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (149)
1 – 10 of 149
TNFRSF19
Tbio
Novelty: 0.01295599
p_int: 0.999583876
p_ni: 0.000416124
Data Source: BioPlex
FCF1
Tdark
Novelty: 0.04202976
p_int: 0.996378016
p_ni: 0.003621984
Data Source: BioPlex
KLHL11
Tbio
Novelty: 0.1537041
p_int: 0.992998217
p_ni: 0.007001776
p_wrong: 7e-9
Data Source: BioPlex
CDK15
Tchem
Family: Kinase
Novelty: 0.3870338
p_int: 0.99202295
p_ni: 0.00797705
Score: 0.183
Data Source: BioPlex,STRINGDB
SINHCAF
Tdark
Novelty: 0.18692832
p_int: 0.983260232
p_ni: 0.016739768
Data Source: BioPlex
KHDC4
Tdark
Novelty: 0.47115316
p_int: 0.980622503
p_ni: 0.019377497
Data Source: BioPlex
KIR3DS1
Tdark
p_int: 0.980522369
p_ni: 0.019477631
Data Source: BioPlex
GDF5
Tbio
Novelty: 0.00218118
p_int: 0.979159184
p_ni: 0.020840816
Data Source: BioPlex
TBC1D22B
Tbio
Novelty: 0.49852962
p_int: 0.977957018
p_ni: 0.022042982
Score: 0.158
Data Source: BioPlex,STRINGDB
DDX19B
Tbio
Family: Enzyme
Novelty: 0.0504568
p_int: 0.973619253
p_ni: 0.026380747
Data Source: BioPlex
Publication Statistics
PubMed Score  32.98

PubMed score by year
PubTator Score  16.21

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer