Tbio BFAR Bifunctional apoptosis regulator

Protein Summary

Description

Apoptosis regulator. Has anti-apoptotic activity, both for apoptosis triggered via death-receptors and via mitochondrial factors.

Uniprot Accession IDs

• Q9NZS9
• A8K4Z9
• B4DUT0
• D3DUG8

Gene Name

• BFAR

Ensembl ID

• ENST00000261658
• ENSP00000261658
• ENSG00000103429
• ENST00000619034
• ENSP00000478190
• ENSG00000275618

Symbol

• BAR
• RNF47
• BAR
• RNF47

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.98
transcription factor perturbation	0.91
protein domain	0.85
transcription factor binding site profile	0.7
disease perturbation	0.62

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.14   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 202   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.14   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0