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Tbio
BFAR
Bifunctional apoptosis regulator

Protein Summary
Description
Apoptosis regulator. Has anti-apoptotic activity, both for apoptosis triggered via death-receptors and via mitochondrial factors.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261658
  • ENSP00000261658
  • ENSG00000103429
  • ENST00000619034
  • ENSP00000478190
  • ENSG00000275618

Symbol
  • BAR
  • RNF47
  • BAR
  • RNF47
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.98
transcription factor perturbation
0.91
protein domain
0.85
transcription factor binding site profile
0.7
disease perturbation
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.88   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 202   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.88   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (38)
PDXDC1
Tbio
Family:  Enzyme
Novelty:  0.16529476
Score:  0.905
Data Source:  STRINGDB
NOMO1
Tbio
Novelty:  0.13625697
Score:  0.753
Data Source:  STRINGDB
ZC3H12A
Tbio
Family:  Enzyme
Novelty:  0.00651373
Score:  0.716
Data Source:  STRINGDB
UBA52
Tbio
Novelty:  0.01637744
Score:  0.716
Data Source:  STRINGDB
CAAP1
Tbio
Family:  Enzyme
Novelty:  0.01569048
Score:  0.648
Data Source:  STRINGDB
TNFRSF10C
Tbio
Novelty:  0.0088942
Score:  0.647
Data Source:  STRINGDB
AHNAK
Tbio
Novelty:  0.01201996
Score:  0.576
Data Source:  STRINGDB
NDUFAF1
Tclin
Novelty:  0.05630549
Score:  0.559
Data Source:  STRINGDB
UBC
Tbio
Novelty:  0.00204643
Score:  0.538
Data Source:  STRINGDB
TMBIM6
Tbio
Novelty:  0.00151958
Score:  0.528
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
55.2
self reported educational attainment
1
1
1
55.2
mathematical ability
1
1
1
52
mathematical ability
1
1
1
52
Items per page:
1 – 4 of 4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
55.2
self reported educational attainment
1
55.2
mathematical ability
1
52
mathematical ability
1
52
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
bifunctional apoptosis regulator
VGNC:13670
738906
Macaque
bifunctional apoptosis regulator
713053
Mouse
MGI:1914368
67118
Rat
RGD:1304791
304709
Dog
bifunctional apoptosis regulator
VGNC:38439
489998
Species
Name
OMA
EggNOG
Inparanoid
Chimp
bifunctional apoptosis regulator
Macaque
bifunctional apoptosis regulator
Mouse
Rat
Dog
bifunctional apoptosis regulator
Publication Statistics
PubMed Score 16.88
PubMed score by year
PubTator Score 56.52
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title