Tbio KLRF1 Killer cell lectin-like receptor subfamily F member 1

Protein Summary

Description

Involved in the natural killer (NK)-mediated cytolysis of PHA-induced lymphoblasts. KLRF1, an activating homodimeric C-type lectin-like receptor (CTLR), is expressed on nearly all natural killer (NK) cells and stimulates their cytoxicity and cytokine release (Kuttruff et al., 2009 [PubMed 18922855]).[supplied by OMIM, Oct 2009]

Uniprot Accession IDs

• Q9NZS2
• Q4KMT5
• Q96PR2
• Q96PR3
• Q9NZS1
• Lectin-like receptor F1

Gene Name

• KLRF1

Ensembl ID

• ENST00000354855
• ENSP00000346919
• ENSG00000150045
• ENST00000612321
• ENSP00000483880

Symbol

• CLEC5C
• ML
• NKp80
• CLEC5C

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.74
cell type or tissue	0.58
cell line	0.57
tissue	0.45
protein domain	0.41

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.94   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 209   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.94   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 209   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0