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Tbio
KLRF1
Killer cell lectin-like receptor subfamily F member 1

Protein Summary
Description
Involved in the natural killer (NK)-mediated cytolysis of PHA-induced lymphoblasts. KLRF1, an activating homodimeric C-type lectin-like receptor (CTLR), is expressed on nearly all natural killer (NK) cells and stimulates their cytoxicity and cytokine release (Kuttruff et al., 2009 [PubMed 18922855]).[supplied by OMIM, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354855
  • ENSP00000346919
  • ENSG00000150045
  • ENST00000612321
  • ENSP00000483880

Symbol
  • CLEC5C
  • ML
  • NKp80
  • CLEC5C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.74
cell type or tissue
0.58
cell line
0.57
tissue
0.45
protein domain
0.41


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.7   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 209   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.7   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 209   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
5
7
8
99.4
lymphocyte percentage of leukocytes
2
4
5
96.6
neutrophil percentage of leukocytes
2
3
3
89.7
3
3
0
1.1
89
leukocyte count
2
3
3
83.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
8
99.4
lymphocyte percentage of leukocytes
5
96.6
neutrophil percentage of leukocytes
3
89.7
0
1.1
89
leukocyte count
3
83.5
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
killer cell lectin like receptor F1
VGNC:8434
465281
Macaque
killer cell lectin like receptor F1
574389
Dog
killer cell lectin like receptor F1
VGNC:54318
611429
Cow
killer cell lectin like receptor F1
VGNC:30685
613393
Pig
killer cell lectin like receptor F1
100144592
Species
Name
OMA
EggNOG
Inparanoid
Chimp
killer cell lectin like receptor F1
Macaque
killer cell lectin like receptor F1
Dog
killer cell lectin like receptor F1
Cow
killer cell lectin like receptor F1
Pig
killer cell lectin like receptor F1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NZS2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Protein-Protein Interactions (67)
1 – 10 of 67
REEP6
Tbio
Novelty:  0.10645981
p_int:  0.981406863
p_ni:  0.018593108
p_wrong:  2.9e-8
Score:  0.747
Data Source:  BioPlex,STRINGDB
GAPDHS
Tbio
Family:  Enzyme
Novelty:  0.00885959
p_int:  0.968518642
p_ni:  0.03148134
p_wrong:  1.8e-8
Score:  0.195
Data Source:  BioPlex,STRINGDB
TOMM40
Tbio
Novelty:  0.0041507
p_int:  0.879009511
p_ni:  0.120990487
p_wrong:  1e-9
Score:  0.211
Data Source:  BioPlex,STRINGDB
REEP5
Tbio
Novelty:  0.00160455
p_int:  0.845842473
p_ni:  0.154157525
p_wrong:  2e-9
Score:  0.512
Data Source:  BioPlex,STRINGDB
CBWD1
Tbio
Novelty:  0.04321511
p_int:  0.835825182
p_ni:  0.164174818
Data Source:  BioPlex
CLEC2B
Tbio
Novelty:  0.06581244
Score:  0.936
Data Source:  Reactome,STRINGDB
SLAMF6
Tbio
Novelty:  0.01459284
Score:  0.756
Data Source:  STRINGDB
NCR3
Tbio
Novelty:  0.00428788
Score:  0.732
Data Source:  STRINGDB
NCR2
Tbio
Novelty:  0.00685029
Score:  0.731
Data Source:  STRINGDB
NCR1
Tbio
Novelty:  0.00282259
Score:  0.717
Data Source:  STRINGDB
Publication Statistics
PubMed Score  16.70

PubMed score by year
PubTator Score  15.23

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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