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Tbio
VSX1
Visual system homeobox 1

Protein Summary
Description
Binds to the 37-bp core of the locus control region (LCR) of the red/green visual pigment gene cluster. May regulate the activity of the LCR and the cone opsin genes at earlier stages of development. The protein encoded by this gene contains a paired-like homeodomain and binds to the core of the locus control region of the red/green visual pigment gene cluster. The encoded protein may regulate expression of the cone opsin genes early in development. Mutations in this gene can cause posterior polymorphous corneal dystrophy and keratoconus. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376707
  • ENSP00000365897
  • ENSG00000100987
  • ENST00000376709
  • ENSP00000365899
  • ENST00000409285
  • ENSP00000386612
  • ENST00000409958
  • ENSP00000387069
  • ENST00000429762
  • ENSP00000401690
  • ENST00000444511
  • ENSP00000387720

Symbol
  • RINX
  • PPD
  • KTCN
  • PPCD
  • RINX
  • KTCN1
  • PPCD1
  • CAASDS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.63
cell line
0.59
protein domain
0.58
biological process
0.52
phenotype
0.51


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.31   (req: < 5)
Gene RIFs: 36   (req: <= 3)
Antibodies: 142   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.31   (req: >= 5)
Gene RIFs: 36   (req: > 3)
Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gut microbiome measurement
1
1
0
3.5
5.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gut microbiome measurement
0
3.5
5.3
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1890816
114889
Rat
RGD:1305667
689704
Dog
visual system homeobox 1
VGNC:48312
608128
Cow
visual system homeobox 1
VGNC:36845
286802
Pig
visual system homeobox 1
100620386
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
visual system homeobox 1
Cow
visual system homeobox 1
Pig
visual system homeobox 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NZR4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (58)
1 – 10 of 58
CSNK2A1
Tchem
Family: Kinase
Novelty: 0.00187855
p_int: 0.999996742
p_ni: 0.000003258
Score: 0.547
Data Source: BioPlex,STRINGDB
CSNK2A2
Tchem
Family: Kinase
Novelty: 0.00231447
p_int: 0.999989373
p_ni: 0.000010627
Score: 0.196
Data Source: BioPlex,STRINGDB
CSNK2B
Tbio
Family: Kinase
Novelty: 0.00152367
p_int: 0.999449921
p_ni: 0.000550078
p_wrong: 1e-9
Score: 0.189
Data Source: BioPlex,STRINGDB
HIST2H2AC
Tbio
Novelty: 0.00065524
p_int: 0.998583016
p_ni: 0.001350614
p_wrong: 0.000066369
Score: 0.28
Data Source: BioPlex,STRINGDB
USP12
Tbio
Family: Enzyme
Novelty: 0.0460009
p_int: 0.86198408
p_ni: 0.031058306
p_wrong: 0.106957614
Score: 0.23
Data Source: BioPlex,STRINGDB
HSPA8
Tchem
Novelty: 0.00081014
p_int: 0.859759686
p_ni: 0.140240314
Data Source: BioPlex
TUBA1A
Tchem
Novelty: 0.01030145
p_int: 0.821570579
p_ni: 0.178429421
Score: 0.226
Data Source: BioPlex,STRINGDB
NXNL1
Tbio
Novelty: 0.03766112
Score: 0.805
Data Source: STRINGDB
ATOH7
Tbio
Family: TF
Novelty: 0.00536814
Score: 0.783
Data Source: STRINGDB
BHLHE23
Tdark
Family: TF
Novelty: 0.02417856
Score: 0.743
Data Source: STRINGDB
Publication Statistics
PubMed Score  91.31

PubMed score by year
PubTator Score  52

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer