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Tbio
TMOD2
Tropomodulin-2

Protein Summary
Description
Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity). This gene encodes a neuronal-specific member of the tropomodulin family of actin-regulatory proteins. The encoded protein caps the pointed end of actin filaments preventing both elongation and depolymerization. The capping activity of this protein is dependent on its association with tropomyosin. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Dec 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000249700
  • ENSP00000249700
  • ENSG00000128872
  • ENST00000435126
  • ENSP00000404590

Symbol
  • NTMOD
  • NTMOD
  • N-TMOD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.86
microRNA
0.8
histone modification site profile
0.7
tissue sample
0.66
biological process
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.47   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 174   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.47   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
22.9
intelligence
1
1
1
21.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
22.9
intelligence
1
21.4
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
tropomodulin 2
694355
Mouse
MGI:1355335
50876
Rat
RGD:61948
58814
Dog
tropomodulin 2
VGNC:47624
478309
Horse
tropomodulin 2
VGNC:24333
100055095
Species
Name
OMA
EggNOG
Inparanoid
Macaque
tropomodulin 2
Mouse
Rat
Dog
tropomodulin 2
Horse
tropomodulin 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NZR1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (2)
Muscle contraction (R-HSA-397014)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Muscle contraction
Reactome
Striated Muscle Contraction
Name
Explore in Pharos
Explore in Source
Muscle contraction
Striated Muscle Contraction
Gene Ontology Terms (12)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (82)
1 – 10 of 82
SCIN
Tbio
Novelty: 0.0080322
p_int: 0.999986837
p_ni: 0.000013163
Score: 0.751
Data Source: BioPlex,STRINGDB
LSP1
Tbio
Novelty: 0.00889927
p_int: 0.991284549
p_ni: 0.008715451
Score: 0.737
Data Source: BioPlex,STRINGDB
RBM18
Tdark
Novelty: 5.77641942
p_int: 0.990743786
p_ni: 0.009256214
Score: 0.807
Data Source: BioPlex,STRINGDB
GSN
Tbio
Novelty: 0.00060852
p_int: 0.975667457
p_ni: 0.024332543
Score: 0.863
Data Source: BioPlex,STRINGDB
AVIL
Tbio
Novelty: 0.0175973
p_int: 0.966088172
p_ni: 0.033911828
Score: 0.193
Data Source: BioPlex,STRINGDB
MYO6
Tbio
Novelty: 0.01073438
p_int: 0.956786908
p_ni: 0.043213092
Score: 0.671
Data Source: BioPlex,STRINGDB
RRM2B
Tbio
Family: Enzyme
Novelty: 0.00817283
p_int: 0.944005862
p_ni: 0.055994138
Score: 0.252
Data Source: BioPlex,STRINGDB
SSH1
Tbio
Family: Enzyme
Novelty: 0.02079383
p_int: 0.929477241
p_ni: 0.070522759
Score: 0.79
Data Source: BioPlex,STRINGDB
SLC25A41
Tdark
Family: Transporter
Novelty: 1.04918395
p_int: 0.907290314
p_ni: 0.092709686
Data Source: BioPlex
PLEKHG6
Tbio
Novelty: 0.15989022
p_int: 0.899707978
p_ni: 0.100292022
Score: 0.477
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  10.47

PubMed score by year
PubTator Score  2.7

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer