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Tchem
TRPM5
Transient receptor potential cation channel subfamily M member 5

Protein Summary
Description
Voltage-modulated Ca(2+)-activated, monovalent cation channel (VCAM) that mediates a transient membrane depolarization and plays a central role in taste transduction. Monovalent-specific, non-selective cation channel that mediates the transport of Na(+), K(+) and Cs(+) ions equally well. Activated directly by increases in intracellular Ca(2+), but is impermeable to it. Gating is voltage-dependent and displays rapid activation and deactivation kinetics upon channel stimulation even during sustained elevations in Ca(2+). Also activated by a fast intracellular Ca(2+) increase in response to inositol 1,4,5-triphosphate-producing receptor agonists. The channel is blocked by extracellular acidification. External acidification has 2 effects, a fast reversible block of the current and a slower irreversible enhancement of current inactivation. Is a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000155858
  • ENSP00000155858
  • ENSG00000070985

Symbol
  • LTRPC5
  • MTR1
  • MTR1
  • LTRPC5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.81
cell type or tissue
0.75
cell line
0.56
tissue
0.48
chemical
0.47


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 149.98   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 147   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 149.98   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 64
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
flufenamic acid
Rendered image for flufenamic acid
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
2
3
176
13.2
97.7
QT interval
7
6
2
2.8
94.4
T wave morphology measurement
3
1
3
85.4
neutrophil count
2
1
2
68.3
mean reticulocyte volume
1
1
1
66.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
176
13.2
97.7
QT interval
2
2.8
94.4
T wave morphology measurement
3
85.4
neutrophil count
2
68.3
mean reticulocyte volume
1
66.8
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
transient receptor potential cation channel subfamily M member 5
705070
Mouse
MGI:1861718
56843
Rat
RGD:1310620
365391
Dog
transient receptor potential cation channel subfamily M member 5
VGNC:47876
483668
Horse
transient receptor potential cation channel subfamily M member 5
VGNC:24559
100060376
Species
Name
OMA
EggNOG
Inparanoid
Macaque
transient receptor potential cation channel subfamily M member 5
Mouse
Rat
Dog
transient receptor potential cation channel subfamily M member 5
Horse
transient receptor potential cation channel subfamily M member 5
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NZQ8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Ion channel transport (R-HSA-983712)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Stimuli-sensing channels
Reactome
TRP channels
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Stimuli-sensing channels
TRP channels
Transport of small molecules
Gene Ontology Terms (12)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (79)
1 – 10 of 79
GNAT3
Tbio
Novelty:  0.00702357
Score:  0.873
Data Source:  STRINGDB
TAS1R3
Tbio
Family:  GPCR
Novelty:  0.00370936
Score:  0.86
Data Source:  STRINGDB
TAS1R2
Tbio
Family:  GPCR
Novelty:  0.00568766
Score:  0.825
Data Source:  STRINGDB
PKD1L3
Tbio
Family:  IC
Novelty:  0.0517368
Score:  0.814
Data Source:  STRINGDB
TRPV1
Tclin
Family:  IC
Novelty:  0.00039493
Score:  0.795
Data Source:  STRINGDB
TAS1R1
Tbio
Family:  GPCR
Novelty:  0.00913004
Score:  0.787
Data Source:  STRINGDB
CALHM1
Tbio
Family:  IC
Novelty:  0.01742976
Score:  0.787
Data Source:  STRINGDB
PKD2L1
Tchem
Family:  IC
Novelty:  0.01605232
Score:  0.768
Data Source:  STRINGDB
TRPV2
Tchem
Family:  IC
Novelty:  0.00472952
Score:  0.75
Data Source:  STRINGDB
PLCB2
Tbio
Family:  Enzyme
Novelty:  0.00571285
Score:  0.738
Data Source:  STRINGDB
Publication Statistics
PubMed Score  149.98

PubMed score by year
PubTator Score  53.56

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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