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Tclin
CD274
Programmed cell death 1 ligand 1

Protein Summary
Description
Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/CD279, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed:11015443). The PDCD1/CD279-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (PubMed:28813417, PubMed:28813410). Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (PubMed:10581077). This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is impo ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381573
  • ENSP00000370985
  • ENSG00000120217
  • ENST00000381577
  • ENSP00000370989

Symbol
  • B7H1
  • PDCD1L1
  • PDCD1LG1
  • PDL1
  • B7-H
  • B7H1
  • PDL1
  • PD-L1
  • PDCD1L1
  • PDCD1LG1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
biological term
0.99
histone modification site profile
0.78
protein domain
0.73
biological process
0.72


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9026.9   (req: < 5)
Gene RIFs: 963   (req: <= 3)
Antibodies: 1403   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9026.9   (req: >= 5)
Gene RIFs: 963   (req: > 3)
Antibodies: 1403   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CD274 molecule
VGNC:4652
464981
Macaque
CD274 molecule
716043
Mouse
MGI:1926446
60533
Rat
RGD:1566211
499342
Dog
CD274 molecule
VGNC:38942
484186
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CD274 molecule
Macaque
CD274 molecule
Mouse
Rat
Dog
CD274 molecule
Protein Structure (24 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NZQ7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 24
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (42)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Costimulation by the CD28 family
Reactome
Immune System
Reactome
PD-1 signaling
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Costimulation by the CD28 family
Immune System
PD-1 signaling
Gene Ontology Terms (26)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (409)
1 – 10 of 409
ATR
Tchem
Family: Kinase
Novelty: 0.00196978
p_int: 0.999980106
p_ni: 0.000019894
Score: 0.155
Data Source: BioPlex,STRINGDB
CDK5RAP3
Tbio
Novelty: 0.03628071
p_int: 0.99995421
p_ni: 0.00004579
Data Source: BioPlex
XPO4
Tbio
Novelty: 0.01507446
p_int: 0.999045264
p_ni: 0.000954736
Data Source: BioPlex
XPO7
Tbio
Novelty: 0.05412704
p_int: 0.998852991
p_ni: 0.001147009
Data Source: BioPlex
UTP20
Tbio
Novelty: 0.09170451
p_int: 0.997525367
p_ni: 0.002474633
Data Source: BioPlex
DOLK
Tbio
Family: Enzyme
Novelty: 0.00664639
p_int: 0.996846914
p_ni: 0.003124411
p_wrong: 0.000028675
Data Source: BioPlex
SLC39A11
Tbio
Family: Transporter
Novelty: 0.09770302
p_int: 0.996589886
p_ni: 0.003410114
Data Source: BioPlex
COG1
Tbio
Novelty: 0.0124285
p_int: 0.9960942
p_ni: 0.0039058
Score: 0.669
Data Source: BioPlex,STRINGDB
MTOR
Tclin
Family: Kinase
Novelty: 0.00012333
p_int: 0.994104629
p_ni: 0.005895371
Score: 0.532
Data Source: BioPlex,STRINGDB
THADA
Tbio
Novelty: 0.06983966
p_int: 0.990061959
p_ni: 0.009938041
Data Source: BioPlex
Publication Statistics
PubMed Score  9026.90

PubMed score by year
PubTator Score  2671.42

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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