Tbio NCKIPSD NCK-interacting protein with SH3 domain

Protein Summary

Description

Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo (By similarity). In vitro, stimulates N-WASP-induced ARP2/3 complex activation in the absence of CDC42 (By similarity). May play an important role in the maintenance of sarcomeres and/or in the assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerization and cell adhesion. Plays a role in angiogenesis. The protein encoded by this gene is localized exclusively in the cell nucleus. It plays a role in signal transduction, and may function in the maintenance of sarcomeres and in the assembly of myofibrils into sarcomeres. It also plays an important role in stress fiber formation. The gene is involved in therapy-related leukemia by a chromosomal translocation t(3;11)(p21;q23) that involves this gene and the myeloid/lymphoid leukemia gene. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

Uniprot Accession IDs

• Q9NZQ3
• B4DFL5
• Q6GU34
• Q6SPF3
• Q8TC10
• Q9UGM8

Gene Name

• NCKIPSD

Ensembl ID

• ENST00000294129
• ENSP00000294129
• ENSG00000213672
• ENST00000416649
• ENSP00000389059

Symbol

• AF3P21
• SPIN90
• DIP
• DIP1
• ORF1
• WISH
• VIP54
• AF3P21
• SPIN90
• WASLBP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	1
histone modification site profile	0.74
hub protein	0.71
virus	0.66
transcription factor binding site profile	0.65

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.78   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 121   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.78   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 121   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0