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Tbio
NCKIPSD
NCK-interacting protein with SH3 domain

Protein Summary
Description
Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo (By similarity). In vitro, stimulates N-WASP-induced ARP2/3 complex activation in the absence of CDC42 (By similarity). May play an important role in the maintenance of sarcomeres and/or in the assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerization and cell adhesion. Plays a role in angiogenesis. The protein encoded by this gene is localized exclusively in the cell nucleus. It plays a role in signal transduction, and may function in the maintenance of sarcomeres and in the assembly of myofibrils into sarcomeres. It also plays an important role in stress fiber formation. The gene is involved in therapy-related leukemia by a chromosomal translocation t(3;11)(p21;q23) that involves this gene and the myeloid/lymphoid leukemia gene. Alternative splicing results in multiple transcript variants of this gene. [provided by ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000294129
  • ENSP00000294129
  • ENSG00000213672
  • ENST00000416649
  • ENSP00000389059

Symbol
  • AF3P21
  • SPIN90
  • DIP
  • DIP1
  • ORF1
  • WISH
  • VIP54
  • AF3P21
  • SPIN90
  • WASLBP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
histone modification site profile
0.74
hub protein
0.71
virus
0.66
transcription factor binding site profile
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.4   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 121   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.4   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 121   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (8)
Fcgamma receptor (FCGR) dependent phagocytosis (R-HSA-2029480)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fcgamma receptor (FCGR) dependent phagocytosis
Reactome
Immune System
Reactome
Innate Immune System
Reactome
RHO GTPase Effectors
Reactome
RHO GTPases Activate WASPs and WAVEs
Name
Explore in Pharos
Explore in Source
Fcgamma receptor (FCGR) dependent phagocytosis
Immune System
Innate Immune System
RHO GTPase Effectors
RHO GTPases Activate WASPs and WAVEs
Gene Ontology Terms (10)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (93)
1 – 10 of 93
FCHSD1
Tdark
Novelty: 0.50104384
p_int: 0.999999965
p_ni: 3e-8
p_wrong: 5e-9
Score: 0.5
Data Source: BioPlex,STRINGDB
ITSN2
Tbio
Novelty: 0.01558254
p_int: 0.999999846
p_ni: 1.53e-7
p_wrong: 1e-9
Score: 0.257
Data Source: BioPlex,STRINGDB
PALLD
Tbio
Novelty: 0.00174021
p_int: 0.999999357
p_ni: 6.43e-7
Score: 0.695
Data Source: BioPlex,STRINGDB
GAS7
Tbio
Novelty: 0.03249596
p_int: 0.9999988
p_wrong: 0.000001199
Score: 0.427
Data Source: BioPlex,STRINGDB
ARHGEF6
Tbio
Novelty: 0.02426496
p_int: 0.999996892
p_ni: 0.000003106
p_wrong: 1e-9
Score: 0.744
Data Source: BioPlex,STRINGDB
NCK1
Tbio
Novelty: 0.00554007
p_int: 0.999992378
p_ni: 0.000007129
p_wrong: 4.93e-7
Score: 0.971
Data Source: BioPlex,STRINGDB
GIT1
Tbio
Family: Enzyme
Novelty: 0.01299019
p_int: 0.999985358
p_ni: 0.000014642
Score: 0.607
Data Source: BioPlex,STRINGDB
GIT2
Tbio
Family: Enzyme
Novelty: 0.01986426
p_int: 0.999979184
p_ni: 0.000020816
Score: 0.785
Data Source: BioPlex,STRINGDB
ARHGEF7
Tbio
Novelty: 0.0073993
p_int: 0.99997692
p_ni: 0.00002308
Score: 0.845
Data Source: BioPlex,STRINGDB
ZFYVE9
Tbio
Novelty: 0.0065462
p_int: 0.999945448
p_ni: 0.000054544
p_wrong: 8e-9
Score: 0.173
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  18.40

PubMed score by year
PubTator Score  276.26

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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