Tbio DNAJC27 DnaJ homolog subfamily C member 27

Protein Summary

Description

GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling.

Uniprot Accession IDs

• Q9NZQ0
• Q5JV88
• Q86Y24

Gene Name

• DNAJC27

Ensembl ID

• ENST00000264711
• ENSP00000264711
• ENSG00000115137
• ENST00000380809
• ENSP00000370187
• ENST00000534855
• ENSP00000440086

Symbol

• RABJS
• RBJ
• RBJ
• RabJS

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.93
molecular function	0.91
virus perturbation	0.88
microRNA	0.83
transcription factor binding site profile	0.81

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.77   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 121   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.77   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 121   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0