You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
C1RL
Complement C1r subcomponent-like protein

Protein Summary
Description
Mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000266542
  • ENSP00000266542
  • ENSG00000139178

Symbol
  • C1RL1
  • C1RLP
  • CLSPA
  • C1RL1
  • C1RLP
  • CLSPa
  • C1r-LP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
histone modification site profile
0.84
tissue sample
0.65
virus perturbation
0.64
microRNA
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.15   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 112   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.15   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 112   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
2
3
92.3
docosapentaenoic acid measurement
1
1
1
79.8
fatty acid measurement
1
1
1
79.8
linolenic acid measurement
1
1
1
79.8
arachidonic acid measurement
1
1
1
79.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
92.3
docosapentaenoic acid measurement
1
79.8
fatty acid measurement
1
79.8
linolenic acid measurement
1
79.8
arachidonic acid measurement
1
79.8
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
complement C1r subcomponent like
VGNC:8394
748111
Macaque
complement C1r subcomponent-like protein
722148
Mouse
MGI:2660692
232371
Rat
RGD:1302936
408246
Dog
complement C1r subcomponent like
VGNC:38587
486713
Species
Name
OMA
EggNOG
Inparanoid
Chimp
complement C1r subcomponent like
Macaque
complement C1r subcomponent-like protein
Mouse
Rat
Dog
complement C1r subcomponent like
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NZP8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (24)
1 – 10 of 24
C1R
Tclin
Novelty:  0.00210654
p_int:  0.999962467
p_ni:  5.6e-8
p_wrong:  0.000037478
Score:  0.735
Data Source:  BioPlex,STRINGDB
CD163
Tbio
Novelty:  0.0007415
Score:  0.712
Data Source:  STRINGDB
DAPK2
Tchem
Family:  Kinase
Novelty:  0.02391861
Score:  0.574
Data Source:  STRINGDB
C9
Tchem
Novelty:  0.00749298
Score:  0.568
Data Source:  STRINGDB
CR1
Tbio
Novelty:  0.00157449
Score:  0.539
Data Source:  STRINGDB
APRT
Tchem
Family:  Enzyme
Novelty:  0.00483077
Score:  0.527
Data Source:  STRINGDB
CDADC1
Tbio
Family:  Enzyme
Novelty:  0.43344342
Score:  0.519
Data Source:  STRINGDB
HPX
Tbio
Novelty:  0.00138137
Score:  0.516
Data Source:  STRINGDB
SERPING1
Tbio
Family:  Enzyme
Novelty:  0.00068448
Score:  0.511
Data Source:  STRINGDB
AMZ1
Tdark
Family:  Enzyme
Novelty:  0.246305
Score:  0.508
Data Source:  STRINGDB
Publication Statistics
PubMed Score  7.15

PubMed score by year
PubTator Score  4.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: