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Tbio
AIPL1
Aryl-hydrocarbon-interacting protein-like 1

Protein Classes
Protein Summary
Description
May be important in protein trafficking and/or protein folding and stabilization. Leber congenital amaurosis (LCA) is the most severe inherited retinopathy with the earliest age of onset and accounts for at least 5% of all inherited retinal diseases. Affected individuals are diagnosed at birth or in the first few months of life with nystagmus, severely impaired vision or blindness and an abnormal or flat electroretinogram. The photoreceptor/pineal-expressed gene, AIPL1, encoding aryl-hydrocarbon interacting protein-like 1, is located within the LCA4 candidate region. The encoded protein contains three tetratricopeptide motifs, consistent with chaperone or nuclear transport activity. Mutations in this gene may cause approximately 20% of recessive LCA. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000250087
  • ENSP00000250087
  • ENSG00000129221
  • ENST00000381129
  • ENSP00000370521
  • ENST00000570466
  • ENSP00000461287
  • ENST00000576307
  • ENSP00000459522
  • ENST00000576776
  • ENSP00000460827

Symbol
  • AIPL2
  • LCA4
  • AIPL2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.68
protein domain
0.58
phenotype
0.53
biological process
0.52
cellular component
0.49


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.62   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 320   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.62   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 320   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
aryl hydrocarbon receptor interacting protein like 1
VGNC:9121
468171
Macaque
aryl hydrocarbon receptor interacting protein like 1
574331
Mouse
MGI:2148800
114230
Rat
RGD:70906
59110
Dog
aryl hydrocarbon receptor interacting protein like 1
VGNC:37742
489447
Species
Name
OMA
EggNOG
Inparanoid
Chimp
aryl hydrocarbon receptor interacting protein like 1
Macaque
aryl hydrocarbon receptor interacting protein like 1
Mouse
Rat
Dog
aryl hydrocarbon receptor interacting protein like 1
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NZN9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (13)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (92)
1 – 10 of 92
NUB1
Tbio
Novelty: 0.00736082
Score: 0.985
Data Source: STRINGDB
GUCY2D
Tbio
Family: Kinase
Novelty: 0.00578343
Score: 0.868
Data Source: STRINGDB
AHR
Tchem
Family: TF
Novelty: 0.37065152
Score: 0.868
Data Source: STRINGDB
CRB1
Tbio
Novelty: 0.00560299
Score: 0.855
Data Source: STRINGDB
TULP1
Tbio
Family: TF
Novelty: 0.0192093
Score: 0.813
Data Source: STRINGDB
RDH12
Tbio
Family: Enzyme
Novelty: 0.016003
Score: 0.809
Data Source: STRINGDB
AIP
Tbio
Novelty: 0.00869592
Score: 0.806
Data Source: STRINGDB
LCA5
Tbio
Novelty: 0.0379066
Score: 0.801
Data Source: STRINGDB
CRX
Tbio
Family: TF
Novelty: 0.00278097
Score: 0.8
Data Source: STRINGDB
RPE65
Tbio
Family: Enzyme
Novelty: 0.00147985
Score: 0.793
Data Source: STRINGDB
Publication Statistics
PubMed Score  75.62

PubMed score by year
PubTator Score  58.94

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer