Tbio CNOT2 CCR4-NOT transcription complex subunit 2

Protein Summary

Description

Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of emryonic stem (ES) cell identity. This gene encodes a subunit of the multi-component CCR4-NOT complex. The CCR4-NOT complex regulates mRNA synthesis and degradation and is also thought to be involved in mRNA splicing, transport and localization. The encoded protein interacts with histone deacetylases and functions as a repressor of polymerase II transcription. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]

Uniprot Accession IDs

• Q9NZN8
• Q9H3E0
• Q9NSX5
• Q9NWR6
• Q9P028

Gene Name

• CNOT2

Ensembl ID

• ENST00000229195
• ENSP00000229195
• ENSG00000111596
• ENST00000418359
• ENSP00000412091
• ENST00000551043
• ENSP00000449260
• ENST00000551483
• ENSP00000448883

Symbol

• CDC36
• NOT2
• NOT2
• CDC36
• NOT2H
• HSPC131

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.98
transcription factor perturbation	0.97
biological process	0.86
molecular function	0.84
protein complex	0.84

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Ccr4-not Transcription Complex Subunit 2

DTO Classes

Protein / Transcription Factor / Ccr4-not Transcription Complex Subunit 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.04   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 389   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.04   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 389   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0