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Tbio
IL1RAPL1
Interleukin-1 receptor accessory protein-like 1

Protein Summary
Description
May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel (PubMed:12783849). May activate the MAP kinase JNK (PubMed:15123616). Plays a role in neurite outgrowth (By similarity). During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity). The protein encoded by this gene is a member of the interleukin 1 receptor family and is similar to the interleukin 1 accessory proteins. This protein has an N-terminal signal peptide, three extracellular immunoglobulin Ig-like domains, a transmembrane domain, an intracellular Toll/IL-1R domain, and a long C-terminal tail which interacts with multiple signalling molecules. This gene is located at a region on chromosome X that is associated with a non-syndromic form of X-linked intellectual disability. Deletions and mutations in this gene were found in patients with intellectua ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378993
  • ENSP00000368278
  • ENSG00000169306

Symbol
  • OPHN4
  • IL1R8
  • MRX10
  • MRX21
  • MRX34
  • OPHN4
  • IL1RAPL
  • TIGIRR-2
  • IL1RAPL-1
  • IL-1RAPL-1
  • IL-1-RAPL-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
molecular function
0.9
trait
0.86
biological process
0.65
kinase perturbation
0.54


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.57   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 205   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.57   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 205   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.8
37.6
1
1
0
1.1
33.1
chronotype measurement
1
1
1
28.1
childhood trauma measurement
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.8
37.6
0
1.1
33.1
chronotype measurement
1
28.1
childhood trauma measurement
1
15.8
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interleukin 1 receptor accessory protein like 1
450116
Macaque
interleukin 1 receptor accessory protein like 1
706588
Mouse
MGI:2687319
331461
Rat
RGD:727891
317553
Platypus
interleukin 1 receptor accessory protein like 1
100074745
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interleukin 1 receptor accessory protein like 1
Macaque
interleukin 1 receptor accessory protein like 1
Mouse
Rat
Platypus
interleukin 1 receptor accessory protein like 1
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NZN1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (8)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-1 family signaling
Reactome
Interleukin-38 signaling
Reactome
Neuronal System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-1 family signaling
Interleukin-38 signaling
Neuronal System
Gene Ontology Terms (22)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (95)
1 – 10 of 95
PTPRD
Tbio
Family:  Enzyme
Novelty:  0.01059407
Score:  0.99
Data Source:  STRINGDB
NCS1
Tbio
Novelty:  0.0051468
Score:  0.962
Data Source:  STRINGDB
IL1F10
Tbio
Novelty:  0.01868526
Score:  0.939
Data Source:  Reactome,STRINGDB
MAPK8
Tchem
Family:  Kinase
Novelty:  0.00055723
Score:  0.914
Data Source:  STRINGDB
SHANK1
Tbio
Novelty:  0.01475447
Score:  0.837
Data Source:  STRINGDB
SHANK2
Tbio
Novelty:  0.00710548
Score:  0.835
Data Source:  STRINGDB
DLG4
Tchem
Novelty:  0.00057285
Score:  0.762
Data Source:  STRINGDB
TUSC3
Tbio
Novelty:  0.01388722
Score:  0.731
Data Source:  STRINGDB
VCX3B
Tdark
Novelty:  0.36671023
Score:  0.71
Data Source:  STRINGDB
REEP4
Tbio
Novelty:  0.37950931
Score:  0.71
Data Source:  STRINGDB
Publication Statistics
PubMed Score  70.57

PubMed score by year
PubTator Score  48.84

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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