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Tbio
MAT2B
Methionine adenosyltransferase 2 subunit beta

Protein Summary
Description
Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine (PubMed:10644686, PubMed:23189196, PubMed:25075345). Can bind NADP (in vitro) (PubMed:23189196, PubMed:23425511). The protein encoded by this gene belongs to the methionine adenosyltransferase (MAT) family. MAT catalyzes the biosynthesis of S-adenosylmethionine from methionine and ATP. This protein is the regulatory beta subunit of MAT. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000280969
  • ENSP00000280969
  • ENSG00000038274
  • ENST00000321757
  • ENSP00000325425
  • ENST00000518095
  • ENSP00000428046

Symbol
  • TGR
  • TGR
  • MAT-II
  • SDR23E1
  • MATIIbeta
  • Nbla02999
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
kinase perturbation
0.93
virus perturbation
0.85
transcription factor binding site profile
0.82
transcription factor
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.37   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 219   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.37   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 219   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
3
1
3
60.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
3
60.5
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
methionine adenosyltransferase 2B
VGNC:7085
462245
Macaque
methionine adenosyltransferase 2B
698119
Mouse
MGI:1913667
108645
Rat
RGD:1593534
683630
Dog
methionine adenosyltransferase 2B
VGNC:43038
479301
Species
Name
OMA
EggNOG
Inparanoid
Chimp
methionine adenosyltransferase 2B
Macaque
methionine adenosyltransferase 2B
Mouse
Rat
Dog
methionine adenosyltransferase 2B
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NZL9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (19)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Deubiquitination
Reactome
Metabolism
Reactome
Metabolism of proteins
Reactome
Methylation
Name
Explore in Pharos
Explore in Source
Biological oxidations
Deubiquitination
Metabolism
Metabolism of proteins
Methylation
Gene Ontology Terms (9)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (98)
1 – 10 of 98
MAT1A
Tbio
Family:  Enzyme
Novelty:  0.00384796
p_int:  0.999407323
p_ni:  0.000592677
Score:  0.996
Data Source:  BioPlex,STRINGDB
MAT2A
Tchem
Family:  Enzyme
Novelty:  0.00667707
p_int:  0.998995226
p_ni:  0.001004774
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
BHMT
Tchem
Family:  Enzyme
Novelty:  0.00453508
Score:  0.966
Data Source:  STRINGDB
BHMT2
Tchem
Family:  Enzyme
Novelty:  0.07713739
Score:  0.952
Data Source:  STRINGDB
MTR
Tbio
Family:  Enzyme
Novelty:  0.0006987
Score:  0.942
Data Source:  STRINGDB
DNMT1
Tclin
Family:  Enzyme
Novelty:  0.00042336
Score:  0.939
Data Source:  STRINGDB
DNMT3A
Tclin
Family:  Epigenetic
Novelty:  0.00085974
Score:  0.931
Data Source:  STRINGDB
DNMT3B
Tchem
Family:  Epigenetic
Novelty:  0.00118766
Score:  0.928
Data Source:  STRINGDB
AMD1
Tchem
Family:  Enzyme
Novelty:  0.00231813
Score:  0.923
Data Source:  STRINGDB
TOMM20
Tbio
Novelty:  0.00275824
Score:  0.908
Data Source:  STRINGDB
Publication Statistics
PubMed Score  28.37

PubMed score by year
PubTator Score  24.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer