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Tbio
RGL1
Ral guanine nucleotide dissociation stimulator-like 1

Protein Summary
Description
Probable guanine nucleotide exchange factor.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304685
  • ENSP00000303192
  • ENSG00000143344
  • ENST00000360851
  • ENSP00000354097

Symbol
  • KIAA0959
  • RGL
  • RGL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
microRNA
0.9
protein domain
0.85
transcription factor
0.85
transcription factor binding site profile
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.31   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 126   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.31   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 126   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
6
4
6
70.5
reticulocyte measurement
3
2
3
58.8
chronotype measurement
1
1
1
48.4
aspartate aminotransferase measurement
1
1
1
18.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
6
70.5
reticulocyte measurement
3
58.8
chronotype measurement
1
48.4
aspartate aminotransferase measurement
1
18.4
Pathways (15)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PPARA activates gene expression
Reactome
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
PPARA activates gene expression
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (52)
1 – 10 of 52
RAP1A
Tchem
Family: Enzyme
Novelty: 0.00375413
p_int: 0.999998931
p_ni: 0.000001069
Score: 0.448
Data Source: BioPlex,STRINGDB
ATL2
Tbio
Novelty: 0.03633884
p_int: 0.999944819
p_ni: 0.000055176
p_wrong: 4e-9
Data Source: BioPlex
RAP1B
Tbio
Family: Enzyme
Novelty: 0.00627538
p_int: 0.994434569
p_ni: 0.005149088
p_wrong: 0.000416343
Score: 0.486
Data Source: BioPlex,STRINGDB
ATL3
Tbio
Novelty: 0.05295598
p_int: 0.9936165
p_ni: 0.006383405
p_wrong: 9.5e-8
Data Source: BioPlex
NRAS
Tchem
Family: Enzyme
Novelty: 0.00080922
p_int: 0.992725058
p_ni: 0.007274634
p_wrong: 3.08e-7
Score: 0.92
Data Source: BioPlex,STRINGDB
HRAS
Tchem
Family: Enzyme
Novelty: 0.00008069
p_int: 0.992532424
p_ni: 0.007165967
p_wrong: 0.000301609
Score: 0.948
Data Source: BioPlex,STRINGDB
TULP3
Tbio
Family: TF
Novelty: 0.06911636
p_int: 0.988158857
p_ni: 0.001293655
p_wrong: 0.010547488
Data Source: BioPlex
RRAS2
Tbio
Family: Enzyme
Novelty: 0.01870067
p_int: 0.960530839
p_ni: 0.039469161
Score: 0.895
Data Source: BioPlex,STRINGDB
LENG8
Tdark
Novelty: 0.66682078
p_int: 0.817054466
p_ni: 0.182854507
p_wrong: 0.000091028
Data Source: BioPlex
RALB
Tbio
Family: Enzyme
Novelty: 0.01605746
Score: 0.936
Data Source: STRINGDB
Publication Statistics
PubMed Score  102.31

PubMed score by year
PubTator Score  28.27

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer