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Tbio
ZNF224
Zinc finger protein 224

Protein Summary
Description
May be involved in transcriptional regulation as a transcriptional repressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells. This gene encodes a member of the Krueppel C2H2-type zinc-finger family of proteins. The encoded protein represses transcription of the aldolase A gene, which encodes a key enzyme in glycolysis. The encoded zinc-finger protein may also function as a transcriptional co-activator with Wilms' tumor protein 1 to regulate apoptotic genes in leukemia. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336976
  • ENSP00000337368
  • ENSG00000267680

Symbol
  • BMZF2
  • KOX22
  • ZNF233
  • ZNF255
  • ZNF27
  • BMZF2
  • KOX22
  • ZNF27
  • BMZF-2
  • ZNF233
  • ZNF255
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.61
protein domain
0.58
cell line
0.52
transcription factor binding site profile
0.52
biological process
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.7   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 120   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.7   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 120   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (28)
1 – 10 of 28
PTX3
Tbio
Novelty:  0.00153752
p_int:  0.999988437
p_ni:  0.00001137
p_wrong:  1.93e-7
Score:  0.197
Data Source:  BioPlex,STRINGDB
LRP1B
Tbio
Novelty:  0.01443405
p_int:  0.999832349
p_ni:  0.000167651
Score:  0.158
Data Source:  BioPlex,STRINGDB
LRP4
Tbio
Novelty:  0.01336125
p_int:  0.9995456
p_ni:  0.000454399
p_wrong:  1e-9
Score:  0.169
Data Source:  BioPlex,STRINGDB
SORL1
Tbio
Novelty:  0.00380895
p_int:  0.999392332
p_ni:  0.000607668
Score:  0.228
Data Source:  BioPlex,STRINGDB
ZNF813
Tdark
Family:  TF
Novelty:  0.91341981
p_int:  0.989352867
p_ni:  0.000015206
p_wrong:  0.010631927
Score:  0.29
Data Source:  BioPlex,STRINGDB
LRP2
Tbio
Novelty:  0.00143258
p_int:  0.953993612
p_ni:  0.046006388
Score:  0.177
Data Source:  BioPlex,STRINGDB
NOTCH3
Tchem
Novelty:  0.000953
p_int:  0.857680091
p_ni:  0.137981129
p_wrong:  0.00433878
Score:  0.173
Data Source:  BioPlex,STRINGDB
ALDOA
Tbio
Family:  Enzyme
Novelty:  0.00517474
Score:  0.949
Data Source:  STRINGDB
TRIM28
Tbio
Family:  Epigenetic
Novelty:  0.00778381
Score:  0.946
Data Source:  STRINGDB
EN1
Tbio
Family:  TF
Novelty:  0.00490799
Score:  0.771
Data Source:  STRINGDB
Pathways (4)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Gene Ontology Terms (9)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein B measurement
1
2
2
89.6
low density lipoprotein cholesterol measurement
1
2
2
88.2
total cholesterol measurement
1
2
2
85.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein B measurement
2
89.6
low density lipoprotein cholesterol measurement
2
88.2
total cholesterol measurement
2
85.1
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 224
VGNC:2188
100610569
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 224
Publication Statistics
PubMed Score 17.70
PubMed score by year
PubTator Score 13.59
PubTator score by year