ZNF224
Zinc finger protein 224
Protein Summary
May be involved in transcriptional regulation as a transcriptional repressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells. This gene encodes a member of the Krueppel C2H2-type zinc-finger family of proteins. The encoded protein represses transcription of the aldolase A gene, which encodes a key enzyme in glycolysis. The encoded zinc-finger protein may also function as a transcriptional co-activator with Wilms' tumor protein 1 to regulate apoptotic genes in leukemia. [provided by RefSeq, Jul 2016]
- ENST00000336976
- ENSP00000337368
- ENSG00000267680
- BMZF2
- KOX22
- ZNF233
- ZNF255
- ZNF27
- BMZF2
- KOX22
- ZNF27
- BMZF-2
- ZNF233
- ZNF255
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell type or tissue | 0.61 | ||
protein domain | 0.58 | ||
cell line | 0.52 | ||
transcription factor binding site profile | 0.52 | ||
biological process | 0.51 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 431 (req: < 5)
Gene RIFs: 18 (req: <= 3)
Antibodies: 120 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 431 (req: >= 5)
Gene RIFs: 18 (req: > 3)
Antibodies: 120 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0