Tchem PLA2G2E Group IIE secretory phospholipase A2

Protein Summary

Description

PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a preference for arachidonic-containing phospholipids.

Uniprot Accession IDs

• Q9NZK7
• Q5VXJ8
• GIIE sPLA2

Gene Name

• PLA2G2E

Ensembl ID

• ENST00000375116
• ENSP00000364257
• ENSG00000188784

Symbol

• sPLA2-IIE
• GIIE sPLA2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
metabolite	0.95
drug	0.72
cell type or tissue	0.61
pathway	0.59
disease perturbation	0.56

Protein Classes

PANTHER Classes

Protein / Hydrolase / Lipase / Phospholipase / Group Iie Secretory Phospholipase A2

DTO Classes

Protein / Enzyme / Hydrolase / Lipase / Phospholipase / Group Iie Secretory Phospholipase A2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.61   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 35   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.61   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 35   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 13

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0