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Tchem
PLA2G2E
Group IIE secretory phospholipase A2

Protein Summary
Description
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a preference for arachidonic-containing phospholipids.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375116
  • ENSP00000364257
  • ENSG00000188784

Symbol
  • sPLA2-IIE
  • GIIE sPLA2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
0.95
drug
0.72
cell type or tissue
0.61
pathway
0.59
disease perturbation
0.56


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.63   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 35   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.63   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 35   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 13
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (13)
1 – 10 of 13
CHEMBL148674
chemical structure image
CHEMBL148649
chemical structure image
CHEMBL515637,CHEMBL435488
chemical structure image
CHEMBL446349
chemical structure image
CHEMBL208315
chemical structure image
CHEMBL514692
chemical structure image
CHEMBL506485
chemical structure image
CHEMBL514705
chemical structure image
CHEMBL346196
chemical structure image
CHEMBL514841
chemical structure image
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phospholipase A2 group IIE
VGNC:11770
748864
Mouse
MGI:1349660
26970
Dog
group IIE secretory phospholipase A2
487399
Horse
phospholipase A2 group IIE
VGNC:50744
100071870
Cow
phospholipase A2 group IIE
VGNC:32957
506243
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phospholipase A2 group IIE
Mouse
Dog
group IIE secretory phospholipase A2
Horse
phospholipase A2 group IIE
Cow
phospholipase A2 group IIE
Protein Structure (8 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NZK7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (25)
Acyl chain remodelling of PC (R-HSA-1482788)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acyl chain remodelling of PC
Reactome
Acyl chain remodelling of PE
Reactome
Acyl chain remodelling of PG
Reactome
Acyl chain remodelling of PI
Reactome
Acyl chain remodelling of PS
Name
Explore in Pharos
Explore in Source
Acyl chain remodelling of PC
Acyl chain remodelling of PE
Acyl chain remodelling of PG
Acyl chain remodelling of PI
Acyl chain remodelling of PS
Gene Ontology Terms (18)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (68)
1 – 10 of 68
PLD1
Tchem
Family: Enzyme
Novelty: 0.00608142
Score: 0.8
Data Source: STRINGDB
PLB1
Tbio
Family: Enzyme
Novelty: 0.01628403
Score: 0.78
Data Source: STRINGDB
PLA2G15
Tbio
Family: Enzyme
Novelty: 0.01546393
Score: 0.764
Data Source: STRINGDB
PNPLA7
Tdark
Family: Enzyme
Novelty: 0.11025485
Score: 0.754
Data Source: STRINGDB
PTGS2
Tclin
Family: Enzyme
Novelty: 0.00007089
Score: 0.744
Data Source: STRINGDB
PLD3
Tbio
Family: Enzyme
Novelty: 0.01610007
Score: 0.741
Data Source: STRINGDB
PLD2
Tchem
Family: Enzyme
Novelty: 0.00331129
Score: 0.74
Data Source: STRINGDB
LYPLA1
Tchem
Family: Enzyme
Novelty: 0.01217068
Score: 0.715
Data Source: STRINGDB
PTGS1
Tclin
Family: Enzyme
Novelty: 0.00043214
Score: 0.713
Data Source: STRINGDB
PLA2G16
Tbio
Novelty: 0.02310886
Score: 0.713
Data Source: STRINGDB
Publication Statistics
PubMed Score  4.63

PubMed score by year
PubTator Score  2.07

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer