Tbio ADA2 Adenosine deaminase 2

Protein Summary

Description

Adenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses. Requires elevated adenosine levels for optimal enzyme activity. Binds to cell surfaces via proteoglycans and may play a role in the regulation of cell proliferation and differentiation, independently of its enzyme activity. This gene encodes a member of a subfamily of the adenosine deaminase protein family. The encoded protein is one of two adenosine deaminases found in humans, which regulate levels of the signaling molecule, adenosine. The encoded protein is secreted from monocytes undergoing differentiation and may regulate cell proliferation and differentiation. This gene may be responsible for some of the phenotypic features associated with cat eye syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Uniprot Accession IDs

• Q9NZK5
• A8K9H4
• Q6ICF1
• Q86UB6
• Q8NCJ2
• Q96K41

Gene Name

• ADA2

Ensembl ID

• ENST00000262607
• ENSP00000262607
• ENSG00000093072
• ENST00000330232
• ENSP00000332871
• ENST00000399837
• ENSP00000382731
• ENST00000399839
• ENSP00000382733
• ENST00000647714
• ENSP00000497821

Symbol

• ADGF
• CECR1
• IDGFL
• PAN
• ADGF
• CECR1
• IDGFL
• SNEDS

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Growth Factor / Adenosine Deaminase 2

Protein / Hydrolase / Deaminase / Adenosine Deaminase 2

DTO Classes

Protein / Enzyme / Hydrolase / Deaminase / Adenosine Deaminase 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 162   (req: < 5)

Gene RIFs: 59   (req: <= 3)

Antibodies: 116   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 162   (req: >= 5)

Gene RIFs: 59   (req: > 3)

Antibodies: 116   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0