MTCH1
Mitochondrial carrier homolog 1
Protein Summary
Potential mitochondrial transporter. May play a role in apoptosis. This gene encodes a member of the mitochondrial carrier family. The encoded protein is localized to the mitochondrion inner membrane and induces apoptosis independent of the proapoptotic proteins Bax and Bak. Pseudogenes on chromosomes 6 and 11 have been identified for this gene. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Oct 2012]
- ENST00000373616
- ENSP00000362718
- ENSG00000137409
- ENST00000373627
- ENSP00000362730
- PSAP
- PSAP
- PIG60
- CGI-64
- SLC25A49
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.99 | ||
disease perturbation | 0.96 | ||
cellular component | 0.68 | ||
gene perturbation | 0.68 | ||
transcription factor binding site profile | 0.61 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 12.07 (req: < 5)
Gene RIFs: 14 (req: <= 3)
Antibodies: 136 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 12.07 (req: >= 5)
Gene RIFs: 14 (req: > 3)
Antibodies: 136 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0