You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
EIF2AK3
Eukaryotic translation initiation factor 2-alpha kinase 3

Protein Summary
Description
Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52' during the unfolded protein response (UPR) and in response to low amino acid availability. Converts phosphorylated eIF-2-alpha/EIF2S1 either in a global protein synthesis inhibitor, leading to a reduced overall utilization of amino acids, or to a translation initiation activator of specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function. The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translationa ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303236
  • ENSP00000307235
  • ENSG00000172071

Symbol
  • PEK
  • PERK
  • PEK
  • WRS
  • PERK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
0.96
chemical
0.92
transcription factor binding site profile
0.91
protein domain
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2031.15   (req: < 5)
Gene RIFs: 185   (req: <= 3)
Antibodies: 570   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2031.15   (req: >= 5)
Gene RIFs: 185   (req: > 3)
Antibodies: 570   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 42
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 79
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0