You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
EIF2AK3
Eukaryotic translation initiation factor 2-alpha kinase 3

Protein Summary
Description
Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52' during the unfolded protein response (UPR) and in response to low amino acid availability. Converts phosphorylated eIF-2-alpha/EIF2S1 either in a global protein synthesis inhibitor, leading to a reduced overall utilization of amino acids, or to a translation initiation activator of specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function. The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translationa ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303236
  • ENSP00000307235
  • ENSG00000172071

Symbol
  • PEK
  • PERK
  • PEK
  • WRS
  • PERK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
0.96
chemical
0.92
transcription factor binding site profile
0.91
protein domain
0.85


Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1902.3   (req: < 5)
Gene RIFs: 121   (req: <= 3)
Antibodies: 570   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1902.3   (req: >= 5)
Gene RIFs: 121   (req: > 3)
Antibodies: 570   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 42
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 62
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (62)
1 – 10 of 62
CHEMBL2171124
Rendered image for CHEMBL2171124
CHEMBL3407849
Rendered image for CHEMBL3407849
CHEMBL3407851
Rendered image for CHEMBL3407851
GSK2606414
Rendered image for GSK2606414
CHEMBL1667899
Rendered image for CHEMBL1667899
CHEMBL1667910
Rendered image for CHEMBL1667910
CHEMBL1667911
Rendered image for CHEMBL1667911
CHEMBL3407850
Rendered image for CHEMBL3407850
GSK2656157
Rendered image for GSK2656157
CHEMBL2171126
Rendered image for CHEMBL2171126
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
4
3
4
90.9
appendicular lean mass
2
1
2
70.5
BMI-adjusted hip circumference
2
2
2
60.8
Progressive supranuclear palsy
1
1
0
1.3
57.3
chronotype measurement
1
1
1
40.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
4
90.9
appendicular lean mass
2
70.5
BMI-adjusted hip circumference
2
60.8
Progressive supranuclear palsy
0
1.3
57.3
chronotype measurement
1
40.7
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation initiation factor 2 alpha kinase 3
VGNC:237
459388
Macaque
eukaryotic translation initiation factor 2 alpha kinase 3
699575
Mouse
MGI:1341830
13666
Rat
RGD:70884
29702
Dog
eukaryotic translation initiation factor 2 alpha kinase 3
VGNC:40258
475756
Species
Name
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation initiation factor 2 alpha kinase 3
Macaque
eukaryotic translation initiation factor 2 alpha kinase 3
Mouse
Rat
Dog
eukaryotic translation initiation factor 2 alpha kinase 3
Protein Structure (11 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NZJ5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 11
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (18)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
PERK regulates gene expression
Reactome
Unfolded Protein Response (UPR)
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
PERK regulates gene expression
Unfolded Protein Response (UPR)
Gene Ontology Terms (49)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ParkinsonsUK-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (182)
1 – 10 of 182
RPN2
Tbio
Family:  Enzyme
Novelty:  0.01796569
p_int:  0.999992807
p_ni:  0.000007192
Data Source:  BioPlex
DLK2
Tbio
Novelty:  0.06366405
p_int:  0.999564105
p_ni:  0.000435895
Data Source:  BioPlex
B4GAT1
Tbio
Family:  Enzyme
Novelty:  0.14959923
p_int:  0.998825765
p_ni:  0.001174234
Data Source:  BioPlex
SCN3B
Tbio
Family:  IC
Novelty:  0.0438123
p_int:  0.99871644
p_ni:  0.00128356
Data Source:  BioPlex
P2RX2
Tchem
Family:  IC
Novelty:  0.00241146
p_int:  0.99718514
p_ni:  0.00281486
Data Source:  BioPlex
CHRND
Tclin
Family:  IC
Novelty:  0.0441685
p_int:  0.995260128
p_ni:  0.004739869
p_wrong:  2e-9
Data Source:  BioPlex
ASIC4
Tbio
Family:  IC
Novelty:  0.02912816
p_int:  0.995163385
p_ni:  0.004836551
p_wrong:  6.3e-8
Data Source:  BioPlex
HFE
Tbio
Novelty:  0.00042077
p_int:  0.995101374
p_ni:  0.004898625
p_wrong:  1e-9
Data Source:  BioPlex
PCDHGB4
Tdark
Novelty:  0.25018904
p_int:  0.994676337
p_ni:  0.005323642
p_wrong:  2.1e-8
Data Source:  BioPlex
TMED7
Tdark
Novelty:  0.31193294
p_int:  0.988738074
p_ni:  0.011261893
p_wrong:  3.3e-8
Data Source:  BioPlex
Publication Statistics
PubMed Score  1902.30

PubMed score by year
PubTator Score  880.61

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: