You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
DTL
Denticleless protein homolog

Protein Summary
Description
Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), FBH1, KMT5A and SDE2 (PubMed:16861906, PubMed:16949367, PubMed:16964240, PubMed:17085480, PubMed:18703516, PubMed:18794347, PubMed:18794348, PubMed:19332548, PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613, PubMed:27906959). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication (PubMed:16861906, PubMed:16949367, PubMed:17085480). CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing (PubMed:18794348, PubMed:19332548). KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progressi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366991
  • ENSP00000355958
  • ENSG00000143476

Symbol
  • CDT2
  • CDW1
  • DCAF2
  • L2DTL
  • RAMP
  • CDT2
  • RAMP
  • DCAF2
  • L2DTL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.96
transcription factor perturbation
0.96
kinase perturbation
0.91
PubMedID
0.88
gene perturbation
0.86


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.72   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 200   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.72   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 200   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (337)
CARNMT1
Tbio
Family:  Enzyme
Novelty:  0.28121779
p_int:  0.99999915
p_ni:  8.5e-7
Score:  0.173
Data Source:  BioPlex,STRINGDB
KLK7
Tchem
Family:  Enzyme
Novelty:  0.00757766
p_int:  0.999920658
p_ni:  0.000067275
p_wrong:  0.000012067
Data Source:  BioPlex
CCT3
Tbio
Novelty:  0.01642521
p_int:  0.999808851
p_ni:  0.000191149
Score:  0.22
Data Source:  BioPlex,STRINGDB
PFDN2
Tbio
Novelty:  0.08537716
p_int:  0.999785121
p_ni:  0.000214879
Data Source:  BioPlex
CCT5
Tbio
Novelty:  0.02369118
p_int:  0.999693808
p_ni:  0.000306192
Score:  0.19
Data Source:  BioPlex,STRINGDB
CUL4A
Tchem
Novelty:  0.00917788
p_int:  0.999335019
p_ni:  0.000664981
Score:  0.992
Data Source:  BioPlex,Reactome,STRINGDB
SSSCA1
Tdark
Novelty:  0.53523038
p_int:  0.99878533
p_ni:  0.001214346
p_wrong:  3.24e-7
Data Source:  BioPlex
COPS8
Tbio
Novelty:  0.0408885
p_int:  0.998733835
p_ni:  0.001256424
p_wrong:  0.000009741
Score:  0.913
Data Source:  BioPlex,STRINGDB
GLMN
Tbio
Novelty:  0.01940401
p_int:  0.998481715
p_ni:  0.001350774
p_wrong:  0.000167511
Score:  0.755
Data Source:  BioPlex,STRINGDB
SERPINA12
Tbio
Novelty:  0.00549132
p_int:  0.99845333
p_ni:  0.00154667
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
DNA Damage Bypass (R-HSA-73893)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Damage Bypass
Reactome
DNA Repair
Reactome
Metabolism of proteins
Reactome
Neddylation
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
DNA Damage Bypass
DNA Repair
Metabolism of proteins
Neddylation
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (23)
Find Similar Targets
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
2
1
2
55.2
body height
1
1
1
33.1
platelet crit
1
1
1
30.2
mean corpuscular volume
1
1
1
27.3
lymphocyte count
2
1
2
17.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
2
55.2
body height
1
33.1
platelet crit
1
30.2
mean corpuscular volume
1
27.3
lymphocyte count
2
17.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
denticleless E3 ubiquitin protein ligase homolog
VGNC:6786
469674
Macaque
denticleless E3 ubiquitin protein ligase homolog
711236
Mouse
MGI:1924093
76843
Rat
RGD:1310439
305073
Dog
denticleless E3 ubiquitin protein ligase homolog
VGNC:40113
490279
Species
Name
OMA
EggNOG
Inparanoid
Chimp
denticleless E3 ubiquitin protein ligase homolog
Macaque
denticleless E3 ubiquitin protein ligase homolog
Mouse
Rat
Dog
denticleless E3 ubiquitin protein ligase homolog
Publication Statistics
PubMed Score 71.72
PubMed score by year
PubTator Score 48.61
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title