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Tbio
TFCP2L1
Transcription factor CP2-like protein 1

Protein Summary
Description
Transcription factor that facilitates establishment and maintenance of pluripotency in embryonic stem cells (ESCs) (PubMed:25215486, PubMed:26906118). With KLF2, acts as the major effector of self-renewal that mediates induction of pluripotency downstream of LIF/STAT3 and Wnt/beta-catenin signaling (By similarity). Required for normal duct development in the salivary gland and kidney (By similarity). Coordinates the development of the kidney collecting ducts intercalated (IC) and principal (PC) cells, which regulate acid-base and salt-water homeostasis, respectively (By similarity). Regulates the expression of IC genes including subunits B1 and D2 of the V-ATPase complex, OXGR1, CA12, SLC4A1, AQP6 and IC-specific transcription factor FOXI1 (By similarity). Regulates also the expression of JAG1 and subsequent notch signaling in the collecting duct (By similarity). JAG1 initiates notch signaling in PCs but inhibits notch signaling in ICs (By similarity). Acts as a transcriptional suppres ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263707
  • ENSP00000263707
  • ENSG00000115112

Symbol
  • CRTR1
  • LBP9
  • LBP9
  • CRTR1
  • LBP-9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.85
virus perturbation
0.83
disease perturbation
0.79
biological process
0.72
transcription factor perturbation
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.97   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 260   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.97   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 260   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
4
5
6
90.5
hematocrit
3
2
3
89.4
hemoglobin measurement
3
2
3
89.1
serum urea measurement
1
3
3
88.4
creatinine measurement
2
4
4
84.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
6
90.5
hematocrit
3
89.4
hemoglobin measurement
3
89.1
serum urea measurement
3
88.4
creatinine measurement
4
84.8
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transcription factor CP2 like 1
VGNC:14440
750129
Macaque
transcription factor CP2 like 1
696479
Mouse
MGI:2444691
81879
Rat
RGD:1305456
304741
Dog
transcription factor CP2 like 1
VGNC:47291
610193
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transcription factor CP2 like 1
Macaque
transcription factor CP2 like 1
Mouse
Rat
Dog
transcription factor CP2 like 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NZI6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (19)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (51)
1 – 10 of 51
TFCP2
Tbio
Family:  TF
Novelty:  0.00687548
p_int:  1
Score:  0.513
Data Source:  BioPlex,STRINGDB
ESRRB
Tchem
Family:  NR
Novelty:  0.00620739
Score:  0.837
Data Source:  STRINGDB
CYP11A1
Tclin
Family:  Enzyme
Novelty:  0.00096368
Score:  0.821
Data Source:  STRINGDB
NANOG
Tbio
Family:  TF
Novelty:  0.00054893
Score:  0.786
Data Source:  STRINGDB
POU5F1
Tbio
Family:  TF
Novelty:  0.00033974
Score:  0.693
Data Source:  STRINGDB
TBX3
Tbio
Family:  TF
Novelty:  0.00515507
Score:  0.634
Data Source:  STRINGDB
KLF4
Tbio
Family:  TF
Novelty:  0.00076828
Score:  0.613
Data Source:  STRINGDB
PRDM14
Tbio
Family:  TF; Epigenetic
Novelty:  0.01776592
Score:  0.597
Data Source:  STRINGDB
KLF2
Tbio
Family:  TF
Novelty:  0.00290947
Score:  0.595
Data Source:  STRINGDB
TRIM10
Tbio
Novelty:  0.27685659
Score:  0.593
Data Source:  STRINGDB
Publication Statistics
PubMed Score  29.97

PubMed score by year
PubTator Score  9.08

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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