Tbio KCNIP1 Kv channel-interacting protein 1

Protein Summary

Description

Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Regulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND1/Kv4.1 and KCND2/Kv4.2 currents. Increases the presence of KCND2 at the cell surface. This gene encodes a member of the family of cytosolic voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the neuronal calcium sensor (NCS) family of the calcium binding EF-hand proteins. They associate with Kv4 alpha subunits to form native Kv4 channel complexes. The encoded protein may regulate rapidly inactivating (A-type) currents, and hence neuronal membrane excitability, in response to changes in the concentration of intracellular calcium. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]

Uniprot Accession IDs

• Q9NZI2
• B7Z7B4
• Q3YAD0
• Q3YAD1
• Q3YAD2
• Q3YAD3
• Q5U822
• KChIP1

Gene Name

• KCNIP1

Ensembl ID

• ENST00000377360
• ENSP00000366577
• ENSG00000182132
• ENST00000411494
• ENSP00000395323
• ENST00000434108
• ENSP00000414886
• ENST00000520740
• ENSP00000431102

Symbol

• KCHIP1
• VABP
• VABP
• KCHIP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.96
transcription factor	0.66
phenotype	0.62
tissue sample	0.6
cell line	0.59

Protein Classes

DTO Classes

Protein / Ion Channel / Kv Channel-interacting Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.09   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 281   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.09   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 281   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0