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Tbio
KCNIP1
Kv channel-interacting protein 1

Protein Summary
Description
Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Regulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND1/Kv4.1 and KCND2/Kv4.2 currents. Increases the presence of KCND2 at the cell surface. This gene encodes a member of the family of cytosolic voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the neuronal calcium sensor (NCS) family of the calcium binding EF-hand proteins. They associate with Kv4 alpha subunits to form native Kv4 channel complexes. The encoded protein may regulate rapidly inactivating (A-type) currents, and hence neuronal membrane excitability, in response to changes in the concentration of intracellular calcium. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377360
  • ENSP00000366577
  • ENSG00000182132
  • ENST00000411494
  • ENSP00000395323
  • ENST00000434108
  • ENSP00000414886
  • ENST00000520740
  • ENSP00000431102

Symbol
  • KCHIP1
  • VABP
  • VABP
  • KCHIP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
transcription factor
0.66
phenotype
0.62
tissue sample
0.6
cell line
0.59


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.09   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 281   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.09   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 281   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (79)
KCNIP2
Tbio
Family:  IC
Novelty:  0.01123517
p_int:  0.999999581
p_ni:  4e-9
p_wrong:  4.15e-7
Score:  0.876
Data Source:  BioPlex,Reactome,STRINGDB
KCNIP4
Tbio
Family:  IC
Novelty:  0.00973829
p_int:  0.999990666
p_wrong:  0.000009334
Score:  0.879
Data Source:  BioPlex,Reactome,STRINGDB
TBC1D28
Tdark
Novelty:  8.00988875
p_int:  0.999583251
p_ni:  0.000415138
p_wrong:  0.000001611
Data Source:  BioPlex
KCND3
Tclin
Family:  IC
Novelty:  0.00328276
Score:  0.998
Data Source:  Reactome,STRINGDB
KCND2
Tclin
Family:  IC
Novelty:  0.00297203
Score:  0.997
Data Source:  Reactome,STRINGDB
KCND1
Tclin
Family:  IC
Novelty:  0.03738277
Score:  0.995
Data Source:  Reactome,STRINGDB
KCNC1
Tclin
Family:  IC
Novelty:  0.00252943
Score:  0.901
Data Source:  STRINGDB
KCNA4
Tclin
Family:  IC
Novelty:  0.00362065
Score:  0.778
Data Source:  STRINGDB
DPP6
Tbio
Family:  Enzyme
Novelty:  0.00435138
Score:  0.737
Data Source:  STRINGDB
UHMK1
Tbio
Family:  Kinase
Novelty:  0.04117277
Score:  0.703
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Cardiac conduction (R-HSA-5576891)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Muscle contraction
Reactome
Phase 1 - inactivation of fast Na+ channels
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Muscle contraction
Phase 1 - inactivation of fast Na+ channels
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
viral load
1
1
1
70.6
eosinophil count
3
1
3
51
eosinophil percentage of leukocytes
1
1
1
47.2
educational attainment
1
1
1
40.4
gut microbiome measurement
1
1
1
21.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
viral load
1
70.6
eosinophil count
3
51
eosinophil percentage of leukocytes
1
47.2
educational attainment
1
40.4
gut microbiome measurement
1
21.2
Find similar targets by:
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel interacting protein 1
VGNC:13521
471735
Macaque
potassium voltage-gated channel interacting protein 1
706021
Mouse
MGI:1917607
70357
Rat
RGD:70886
65023
Dog
potassium voltage-gated channel interacting protein 1
VGNC:42254
489125
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel interacting protein 1
Macaque
potassium voltage-gated channel interacting protein 1
Mouse
Rat
Dog
potassium voltage-gated channel interacting protein 1
Publication Statistics
PubMed Score 81.09
PubMed score by year
PubTator Score 31.17
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title