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Tbio
IL36G
Interleukin-36 gamma

Protein Summary
Description
Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1; also stimulates its own expression and that of the prototypic cutaneous proinflammatory parameters TNF-alpha, S100A7/psoriasin and inducible NOS. May play a role in proinflammatory responses during particular neutrophilic airway inflammation: activat ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259205
  • ENSP00000259205
  • ENSG00000136688
  • ENST00000376489
  • ENSP00000365672

Symbol
  • IL1E
  • IL1F9
  • IL1H1
  • IL1RP2
  • IL1E
  • IL1F9
  • IL1H1
  • IL-1F9
  • IL-1H1
  • IL1RP2
  • IL-1RP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.58
tissue sample
0.54
cell line
0.51
cell type or tissue
0.51
transcription factor
0.48


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.27   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 268   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.27   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 268   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (60)
CDK15
Tchem
Family:  Kinase
Novelty:  0.3870338
p_int:  0.969275208
p_ni:  0.028418953
p_wrong:  0.002305839
Data Source:  BioPlex
KIR3DS1
Tdark
p_int:  0.943666313
p_ni:  0.056182312
p_wrong:  0.000151375
Data Source:  BioPlex
KLHL11
Tbio
Novelty:  0.1537041
p_int:  0.842206183
p_ni:  0.157793777
p_wrong:  4e-8
Data Source:  BioPlex
MYL2
Tbio
Novelty:  0.0018887
p_int:  0.839357881
p_ni:  0.160449114
p_wrong:  0.000193005
Score:  0.314
Data Source:  BioPlex,STRINGDB
MUM1
Tbio
Family:  Epigenetic
Novelty:  0.11597088
p_int:  0.787495367
p_ni:  0.212499172
p_wrong:  0.000005461
Data Source:  BioPlex
ZSCAN20
Tdark
Family:  TF
Novelty:  0.37441538
p_int:  0.764423969
p_ni:  0.228582298
p_wrong:  0.006993733
Data Source:  BioPlex
IL1RL2
Tbio
Novelty:  0.0156461
Score:  0.967
Data Source:  Reactome,STRINGDB
IL36RN
Tbio
Novelty:  0.00659649
Score:  0.942
Data Source:  STRINGDB
IL36B
Tbio
Novelty:  0.05952789
Score:  0.927
Data Source:  STRINGDB
IL1F10
Tbio
Novelty:  0.01868526
Score:  0.92
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-1 family signaling
Reactome
Interleukin-36 pathway
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-1 family signaling
Interleukin-36 pathway
Signaling by Interleukins
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
7
6
9
96.6
interleukin 1 receptor antagonist measurement
2
3
3
96.2
interleukin-1 beta measurement
2
57
57
95.4
serum non-albumin protein measurement
1
1
1
57.3
neutrophil count
2
1
2
46.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
9
96.6
interleukin 1 receptor antagonist measurement
3
96.2
interleukin-1 beta measurement
57
95.4
serum non-albumin protein measurement
1
57.3
neutrophil count
2
46.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interleukin 36 gamma
VGNC:49083
738914
Macaque
interleukin 36 gamma
700822
Mouse
MGI:2449929
215257
Rat
RGD:1563019
499744
Horse
interleukin 36 gamma
VGNC:51330
100065031
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interleukin 36 gamma
Macaque
interleukin 36 gamma
Mouse
Rat
Horse
interleukin 36 gamma
Publication Statistics
PubMed Score 22.27
PubMed score by year
PubTator Score 11.14
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title